西北大学 -〉生命科学学院 -〉 师资队伍 -> 段康民
 
 
     
 

 

　　　

段康民

微生物及分子生物学博士，西北大学生命科学学院教授（特聘）、博士生导师。西北大学分子微生物学实验室主任。

通信地址：西北大学生命科学学院，西安市太白北路229号,邮编 710069
Tel: 029-88302132（办）; 029-88305288（实验室）
Fax: 029-88305288
E-mail: kduan@nwu.edu.cn
主要研究方向：
病原菌致病机理及抗药性机理，微生物细胞间的相互作用及信息传递，以及新型抗生素的研究开发。
科研项目：

  1. 科技部重大基础研究前期研究专项项目“病原菌信息传递系统及其为靶点的新型抗致病药物研究”。项目主持人。项目编号：2004CCA01700，执行年限：2005年1月-2006年12月。
  2. 国家自然科学基金项目面上项目"病原菌基因表达和抗药性受抗生素调节的基因组学研究”。项目批准号：30470098，执行年限：2005年1月-2007年12月。
  3. 教育部科学研究重点项目“病原菌信息传递系统及其为靶点的新型‘抗致病药物’研究”。项目主持人。执行年限：2007年1月-2008年12月。
  4. 国家自然科学基金国际合作项目“利用体内高通量基因表达分析系统从天然化合物中筛选抗金黄色葡萄球菌的新型抗生素”。项目主持人。项目批准号：30611120520，执行期限：2007年1月-2009年12月。
  5. 青海省科技厅攻关项目“多功能抗虫害促生长基因工程菌研究”。项目第二负责人。项目编号：2004-J-C04，执行年限：2004年10月-2006年12月。

发表论文及摘要（部分）：

  1. Liang, H., L. Li, Z. Dong, M. Surette, and K. Duan*. (2008) The YebC family protein PA0964 negatively regulates Pseudomonas quinolone signal (PQS) system and pyocyanin production. J. Bacteriol. 190:6217-6227 (西北大学为作者单位，SCI影响因子：4.0) (*corresponding author)
  2. Shen L., Y. Shi., D. Zhang, J. Wei, M. G. Surette, and K. Duan*. (2008) Modulation of secreted virulence factor genes by subinhibitory concentrations of antibiotics in Pseudomonas aeruginosa. J. Microbiol. 46:441-447 (西北大学为作者单位，SCI影响因子：2.05)
  3. Sibley, C.D., M. Parkins, D. G. Storey, H. Rabin, K. Duan, C. Norgaard, and M. G. Surette. (2008) A polymicrobial perspective of pulmonary infections exposes an enigmatic pathogen in cystic fibrosis patients. Proc. Natl. Acad. Sci. USA. (accepted) (西北大学为作者单位，SCI影响因子：9.6)
  4. Han S., J. Ma, Y. Lv, C. Huang, H. Liang, K. Duan*. (2008) Secretory Tat-Apoptin fusion protein induces apoptosis in hepatocellular carcinoma HepG2 cells. World J. Gastroenterol. 14(23):3642-3649 (西北大学为作者单位，SCIE影响因子：3.2)
  5. Sibley, C.D., K. Duan, C. Fischer, M. D. Parkins, D. G. Storey, H. Rabin and M. G. Surette. (2008) Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections. PLOS Pathogens (accepted) (西北大学为作者单位，SCI影响因子：9.3)
  6. Duan, K. and C. D. Sibley, C.J. Davidson, and M. Surette, (2008) Chemical interactions between microorganisms in microbial communities in “Bacterial Signaling” ed. by M. Collin and R. Schuch, a volume in the series ‘Contributions to Microbiology’. Karger AG (西北大学为作者单位)
  7. 赵兴艳，梁海华，沈立新，董兆麟，段康民* （2008）铜绿假单胞菌多重耐药基因的筛选及鉴定.微生物学报. 48(8):1019-1024(西北大学为作者单位)
  8. 王 琰，魏金花，沈立新，段康民* (2008) 铜绿假单胞菌随机启动子库的构建及受铁调控基因的筛选和鉴定.微生物学报.48 (7):863-868. (封面文章) (西北大学为作者单位)
  9. 孔丽萍,梁海华，董兆麟，段康民﹡,沈立新﹡ (2008) 铜绿假单胞菌中一个新的吩嗪合成调节基因.微生物学报 (已接受) (西北大学为作者单位)
  10. Duan, K. and M. Surette (2007) Environmental regulation of Pseudomonas aeruginosa PAO1 las and rhl quorum sensing systems. J. Bacteriol. 189: 4827-4836 (西北大学为作者单位, SCI影响因子：4.0)
  11. Sibley C. D., K. Duan, M. Parkins, D. Storey, H. R. Rabin, and M. G. Surette. (2007) Polymicrobial interactions in CF: synergies and antagonisms in host response. Pediatric Pulmonology 42, S30: 150-151. (西北大学为作者单位, SCI影响因子：2.3)
  12. Song J., K. Duan and M. Surette. (2007) The wavelet-based cluster analysis for temporal gene expression data. EURASIP J. Bioinform. Sys. Biol. doi:10.1155/2007/39382
  13. Xie, J., W. Sun, K. Duan and Y. Zhang (2007) Chemical constituents of roots of Epimedium wushanense and evaluation of their biological activities. Natural Product Research, Vol. 21 (7): 600–605
  14. Duan, K. and M. Surette, (2006) LuxS in cellular metabolism and cell-cell signalling in "Bacterial Cell-to-Cell Communication: Role in Virulence and Pathogenesis" ed. by Donald R. Demuth, Cambridge University Press. (西北大学为作者单位)
  15. Song, J.Z, K. Duan, M. Surette. (2005) The wavelet transformation of temporal gene expression analysis. The Proceedings of the IEEE Computer Vision and Pattern Recognition. V3:148
  16. Duan, K., C. Dammel, J. Stein, H. Rabin, M. G. Surette, (2003) Modulation of Pseudomonas aeruginosa gene expression by host microflora through interspecies communication. Mol. Microbiol. 50:1477-1491
  17. Duan, K., E. R. LaFontaine, S. Majumdar and P. A. Sokol. (2000) RegA, iron, and growth phase regulate expression of the Pseudomonas aeruginosa tol-oprL gene cluster. J. Bacteriol. 182:2077-2087
  18. Duan, K., S. Kim and N. W. Dunn, (1999) Rapid plasmid DNA isolation from Lactococcus lactis using overnight cultures. Biotech. Techniques 13:519-521
  19. Duan, K., C.-Q. Liu, Y. Liu, J. Ren and N. W. Dunn. (1999) Nucleotide sequence and thermostability of pND324, a 3.6-kb plasmidfrom Lactococcus lactis. Appl. Microbiol. Biotech. 55:36-42
  20. Duan, K., C.-Q. Liu, S. Supple and N. W. Dunn. (1998) Involvement of antisense RNA in replication control of the lactococcal plasmid pND324. FEMS Microbiol. Letters. 164:419-426
  21. Duan, K., M. L.Harvey, C.-Q. Liu and N. W. Dunn. (1996) Identification and characterization of a mobilizing plasmid, pND300, in Lactococcus lactis? M189 and its encoded nisin resistance determinant. J. Appl. Bacteriol. 81:493-500
  22. Liu, C.-Q., K. Duan and N. W. Dunn. (1997) Cloning and sequence analysis of a plasmid replicon form Lactococcus lactis subsp. cremoris FG2. J. Gen. Appl. Microbiol. 43:75-80
  23. Duan, K. Bacterial Interactions as Potential Targets for Antiinfective Drug Development. Plenary talk. The 4th Annual Congress of International Drug Discovery Science and Technology. May 24-June 2, 2006, Dalian-Xi’an, China
  24. Duan, K. Transcriptomic analysis of cell-cell signalling in microbial communities. Plenary talk. MicroEnGen-II: 2nd SCOPE-meeting on Microbial Environmental Genomics-Environmental Microbial Ecology in An ‘omics’ Era (June, 2005). Shanghai, China
  25. Song J, K. Duan, T. Ware, M. McCullough, M Surette. The Synthetic Genetic Regulatory Networks For Temporal Gene Expression Analysis. International Plant & Animal Genomes XIV Conference. January 14-18, 2006. San Diego, CA
  26. Duan K., R. Duplisea, C. Dammel, H. Rabin, J. Stein, and M.G. Surette. (2003) AI-2 Mediated Signalling in the Microbial Community in the Lungs of Cystic Fibrosis Patients. 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy. Chicago, USA
  27. Grant, C., M. G. Surette, K. Duan, C. S. Dammel, J. L. Stein; (2003) A Novel Promoter Based Technology for Identification of Targets in Biofilm Growth. ASM conference on Biofilms. Victoria, BC, Canada
  28. Dammel, C., K, Duan, C. Grant, and J. Stein, H. Rabin M. G. Surette. (2002) Inter-Species Communication and the Pathology of Cystic Fibrosis Microbial Communities. 42nd Interscience Conference on Antimicrobial Agents and Chemotherapy. San Diego, USA
  29. Duan, K., R. Duplisea, and M.G. Surette. (2002) Regulation of Pseudomonas aeruginos gene expression by normal flora strains from the CF lungs. Banff Conference on Infectious Diseases. Banff, Canada
  30. Duan, K., M. Visser and P. A. Sokol. (2000) Complex regulation of a potential antibacterial target, the Pseudomonas aeruginosa tol-oprL gene cluster. CBDN Annual Meeting. Canmore, AB, Canada
  31. Duan, K., M. Visser and P. A. Sokol. (2000) The first gene of the tol-oprL cluster, orf1, may plays a role in regulating tol-oprL expression in Pseudomonas aeruginosa. Banff Conference on Infectious Diseases. Panorama, BC, Canada
  32. Duan, K., E. R. LaFontaine, S. Majumdar and P. A. Sokol. (1999) Transcriptional analysis of the tol-pal gene cluster of Pseudomonas aeruginosa. ASM Annual General Meeting. Chicago, IL, USA
  33. Duan, K. and P. A. Sokol. (1999). Iron and growth phase regulated expression of the Pseudomonas aeruginosa tol-pal gene cluster. CBDN Annual Meeting. Banff, AB, Canada
  34. Liu, C –Q., K. Duan, M. Harvey, Y. Y. Liu and N W. Dunn.? (1998). Replication control of a cryptic plasmid, pND324, from Lactococcus lactis. Australiasian Biotechnology Conference. Hobart, Australia
  35. Duan, K., C.-Q. Liu, M. L. Harvey and N. W. Dunn. (1996). Integration vectors based on a thermosensitive plasmid replicon from Lactococcus lactis subsp. lactis M127. 10th International Biotechnology Symposia. Sydney, Australia
  36. Liu, C.-Q., K. Duan and N. W. Dunn. (1995). Cloning and characterization of the replication regions from Lactococcus lactis subsp. Lactis. International Dairy Lactic Acid Bacteria Conference. Palmerstone North, New Zealand

研究机会：我实验室招收微生物学和生化及分子生物学两个方向的硕、博士研究生，研究条件优越。欢迎对科学研究有真正兴趣，勤奋、好学，积极向上的同学报考。

 


  
     
 
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