师资队伍
您当前所在位置是: 首页 >> 师资队伍 >> 师资力量 >> 正文
张英
发布时间:2020-05-21      作者:    点击:[]    分享到:

个人简介

张英,副教授、理学博士、硕士研究生导师;美国糖生物学会、中国化学学会糖化学分会、中国生物化学学会糖生物学分会及中国生物工程学会糖工程学分会会员;兼任Carbohydrate research、Biotechnology等期刊审稿人。2008-2009年在第四军医大学唐都医院中心实验室任助理研究员,从事肿瘤的基因治疗研究;2018-2019年,在美国Emory大学功能糖组学研究中心进行博士后工作,进行糖芯片的构建及应用研究。近年来,专注于糖生物学与糖化学新技术新方法研究,主要研究兴趣为疾病相关糖复合物的分析、检测及作用受体筛查等方法研究。主持并完成国家自然科学基金青年基金、陕西省科技厅及陕西省教育厅自然科学专项等多项基金;参与国家“863”项目、重点研究计划及自然科学基金等多项科研项目;在Glycobiology, Analytica Chimica Acta等期刊发表第一及通讯作者SCI论文近20篇;获中国发明专利授权1项及受理3项;获陕西省高等学校科学技术一等奖、陕西省优秀博士论文及西北大学优秀青年学术骨干支持计划等。

受教育及研究工作经历:
1. 2016/04-至 今,西北大学,生命科学学院,副教授
2. 2017/12-2019/01,美国Emory大学,生物化学系,博士后
3. 2012/07-2016/03,西北大学,生命科学学院,讲师
4. 2009/09-2012/07,西北大学,生命科学学院,博士
5. 2008/07-2009/09,第四军医大学,中心实验室,助理研究员

通信地址:陕西省西安市太白北路229号西北大学生命科学学院,邮编:710069
E-mail: zhangying@nwu.edu.cn

承担的科研项目

(1)陕西省科技厅专项科研计划项目:肿瘤细胞中唾液酸化修饰糖链的活细胞成像和荧光检测新方法研究(2016JQ3018),起止年限:2016.01-2017.12,负责人。
(2)西北大学优秀青年学术骨干支持计划:UDP-2-keto sugar通用型化学合成方法研究,2016.1-2018.12,负责人。
(3)国家自然科学青年基金:O-GlcNAc糖基化修饰的活细胞成像及荧光检测新方法研究(31300678),起止年限:2014.01-2016.12,负责人。
(4)陕西省教育厅专项科研计划项目:活细胞水平O-糖基化修饰荧光检测新方法的建立(2013JK0714),起止年限:2013.07-2015.07,负责人。

主要研究成果

代表性文章:
14. Ying Zhang, Bo Wang, Wanjun Jin, Yanan Wen, Lijing Nan, Mingming Yang, Rendan Liu, Yuyang Zhu, Chengjian Wang, Linjuan Huang, Xuezheng Song and Zhongfu Wang*. Sensitive and robust MALDI-TOF-MS glycomics analysis enabled by Girard's reagent T on-target derivatization (GTOD) of reducing glycans. Analytica Chimica Acta, 2019, 1048: 105-114.
13. Lijing Nan, Jiao Li, Wanjun Jin, Ming Wei, Mengjun Tang, Chengjian Wang, Guiping Gong, Linjuan Huang, Ying Zhang* and Zhongfu Wang*. Comprehensive quali-quantitative profiling of neutral and sialylated O-glycome by mass spectrometry based on oligosaccharide metabolic engineering and isotopic labeling. Rsc Advances, 2019, 9: 15694-15702.
12. Mingming Yang, Lijing Nan, Wanjun Jin, Chengjian Wang, Linjuan Huang, Ying Zhang* and Zhongfu Wang*. Quali-quantitative profiling of mucin-type O-glycans in normal and tumor cell lines based on oligosaccharide metabolic engineering combined with mass spectrometry. Chemical Journal of Chinese Universities, 2018, 39: 1904-1912.
11. Ying Zhang, Yang Liu, Ying Liu, Shan Qiang, Bingying Yang, Linjuan Huang and Zhongfu Wang*. Pretreatment method for detecting of N-linked glycans of glycoprotein in micro-scale complex biological sample based on electrospray ionization mass spectrometry. Chinese Journal of Analytical Chemistry, 2016, 44: 265-272.
10. Guiping Gong, Jiangbo Fan, Yujiao Sun, Yanmin Wu, Yang Liu, Wei Sun, Ying Zhang* and Zhongfu Wang*. Isolation, structural characterization, and antioxidativity of polysaccharide LBLP5-A from Lycium barbarum leaves. Process Biochemistry, 2016. 51: 314-324.
9. Liying Pan, Xiao Gu, Chengjian Wang, Shan Qiang, Linjuan Huang, Ying Zhang* and Zhongfu Wang*. Comparative analysis of O-glycans from human hepatocellular carcinoma HepG2 and normal liver cells L02. Chemical Journal of Chinese Universities, 2015, 36: 1275-1281.
8. Ying Zhang, Chengjian Wang, Yang Liu, Weinan Yao, Yujiao Sun, Ping Zhang, Linjuan Huang and Zhongfu Wang*. Fluorescein-5-thiosemicarbazide (FTSC) labeling for fluorescent imaging of pectin-derived oligogalacturonic acid transported in living cells by confocal microscopy. European Food Research and Technology, 2014, 239: 1-9.
7. Ying Zhang, Jiangbei Yuan, Jingjing Song, Zhongfu Wang and Linjuan Huang*. An efficient method for selectively in situ imaging and quantifying the expression of sialylated glycoproteins on living cells. Glycobiology, 2012, 23: 643-653.
6. Ying Zhang, Yujiao Sun, Zhongfu Wang and Linjuan Huang*. Fluorescein-5-thiosemicarbazide as a probe for directly imaging of mucin-type O-linked glycoprotein within living cells. Glycoconjugate Journal, 2012, 29: 445-452.
5. Ying Zhang, Yang Liu, Zhijun Wang, Zhongfu Wang and Linjuan Huang*. The synthesis of a 2-deoxy-2-acetonyl sugar from its corresponding natural saccharide. Journal of Chemical Research, 2012, 36: 244-246.
4. Ying Zhang, Ping Zhang, Zhongfu Wang and Linjuan Huang*. An Innovative derivatization method for simultaneous determination of uronic acids and neutral and amino sugars in coexisting samples by HPLC-ESI-MS/MS2. Journal of Liquid Chromatography & Related Technologies, 2011, 34: 1754-1771.
3. Ying Zhang, Zhongfu Wang, Xiaorui Zhang, Wenxia Zhou and Linjuan Huang*. One-pot fluorescent labeling of saccharides with fluorescein-5-thiosemicarbazide for imaging polysaccharides transported in living cells. Carbohydrate Research, 2011, 346: 2156-2164.
2. Ying Zhang, Linjuan Huang and Zhongfu Wang*. Techniques for staining glycoprotein on gel electrophoresis or electroblotting. Progress in Chemistry, 2008, 20: 1158-1164.
1. Ying Zhang, Linjuan Huang and Zhongfu Wang*. A sensitive derivatization method for the determination of the sugar composition after pre-column reductive Amination with 3-amino-9-ethylcarbazole (AEC) by high-performance liquid chromatography. Chinese Journal of Chemistry, 2007, 25: 1522-1528.

获得的教学和科研表彰

1. 2014年获评陕西省优秀博士论文奖
2. 2016年获评西北大学优秀青年学术骨干称号
3. 2017年陕西省高等学校科学技术奖一等奖(4/11)