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高云芳
发布时间:2020-05-21      作者:    点击:[]    分享到:

高云芳

博士、教授,博士生导师,动物生理学研究团队带头人,动物生理学省级精品课程负责人。中国动物学会动物生理生态学分会第一届委员,陕西省生理学会常务理事,陕西省动物学会副理事长。

1982年元月本科毕业陕西师范大学生物系。

1989年硕士毕业陕西师范大学生物系动物生理学专业。

2005年博士毕业于西安交通大学医学院生理学专业

2006年-2007年在奥地利航天生理研究所从事博士后研究。

2013年应邀赴奥地利进行国际合作研究。

1992年至今一直在西北大学生命科学学院工作。


通信地址:西北大学生命科学学院,西安市太白北路229号,邮编:710069

E-mail: gaoyunf@nwu.edu.cn


主要研究方向:动物生理学与中药药理学

长期从事动物生理学教学与研究。科研方面主要致力于达乌尔黄鼠冬眠期抗废用性肌萎缩机制的研究与抗废用性肌萎缩药物的研发。主持的《活血化瘀类与补益类药物在抗废用性肌萎缩中的应用研究》荣获2017年陕西省高等学校科学技术奖二等奖主持过多项有关冬眠动物抗废用性肌萎缩机制研究的国家自然科学基金项目,在国内外具有重要影响,处于这一领域的国际领先水平。已发表90余篇学术论文其中SCI收录论文40余, EI收录论文2篇。参编专著《中国国家级自然保护区》1部,教材《生理学》、《人体机能学》、《生理学全攻略》大学生理学4本,其中“十“十”国家级规划教材2本。

在研

国家自然科学基金项目(32070442肌骨交互作用及其共调节因子在冬眠期达乌尔黄鼠运动功能维持中的作用与机制研究2021,1-2024,12, 主持

国家自然科学基金项目(31772459)骨骼肌纤维的钙稳态调控在冬眠达乌尔黄鼠抗废用性肌萎缩中的作用及其机制研究,2018,1-2021,12, 主持

代表性论文:(*通讯作者)(1共同第一作者)

1.Zhang J1, Chang H1, Yin RR, Xu SH, Wang HP, Gao YF*. A temporal study on musculoskeletal morphology and metabolism in hibernating Daurian ground squirrels (Spermophilus dauricus), Bone, 2021, 144: 115826.

2.Xu SH1, Fu WW1, Zhang J, Wang HP, Dang K, Chang H, Gao YF*. Different fuel regulation in two types of myofiber results in different antioxidant strategies in Daurian ground squirrels (Spermophilus dauricus) during hibernation, J Exp Biol, 2020, DOI: 10.1242/jeb.231639.

3.Wang Z1, Zhang J1, Ma XF, Chang H, Peng X, Xu SH, Wang HP*, Gao YF*. A temporal examination of cytoplasmic Ca2+ levels, sarcoplasmic reticulum Ca2+ levels, and Ca2+-handling-related proteins in different skeletal muscles of hibernating Daurian ground squirrels, Front. Physiol, 2020 Oct; DOI: 10.3389/fphys.2020.562080.

4.Dang K1, Yu HJ1, Xu SH1, Ma TR, Wang HP, Li Y, Li Z*, Gao YF*. Remarkable homeostasis of protein sialylation in skeletal muscles of hibernating Daurian ground squirrels (Spermophilus dauricus). Front. Physiol, 2020, 11: 37.

5.Zhang J1, Li XY1, Ismail F, Xu SH, Wang Z, Peng X, Yang CX, Chang H*, Wang HP, Gao YF*. Priority strategy of intracellular Ca2+ homeostasis in skeletal muscle fibers during the multiple stresses of hibernation, Cells, 2020, 9(42). DOI: 10.3390/cells9010042.

6.Wei YH1, Zhang J1,Yan X, Peng X, Xu SH, Chang H, Wang HP, Gao YF*. Remarkable protective effects of Nrf2-mediated antioxidant enzymes and tissue specificity in different skeletal muscles of Daurian ground squirrels over the torpor-arousal cycle, Front. Physiol, 2019 Nov, 10: 1449. DOI: 10.3389/fphys.2019.01449.

7.Zhang J1, Wei YH1, Qu T1, Wang Z, Xu SH, Peng X, Yan X, Chang H, Wang HP, Gao YF*. Prosurvival roles mediated by the PERK signaling pathway effectively prevent excessive endoplasmic reticulum stress-induced skeletal muscle loss during high-stress conditions of hibernation, J Cell Physiol, 2019 Nov; 234(11): 19728-19739. DOI: 10.1002/jcp.28572.

8.Wang Z1, , Jiang SF1, Cao J1, Liu K, Xu SH, Arfat Y, Guo QL, Chang H, Goswami N, Hinghofer-Szalkay H, Gao YF*.Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen. J Cell Physiol. 2019 Aug; 234(8):13318-13331; DOI.org/10.1002/jcp.28008  

9.Dang K1, Gao YG1, Yu HJ, Xu SH, Jiang SF, Zhang WJ, Wang HP, Li Z*, Gao YF*. Regular alteration of protein glycosylation in skeletal muscles of hibernating Daurian ground squirrels (Spermophilus dauricus) Comp Biochem Physiol B Biochem Mol Biol. 2019 Aug: 110323. DOI: 10.1016/j.cbpb.2019.110323.

10.Ma XF1, Chang H1, Wang Z, Xu SH, Peng X, Zhang J, Yan X, Lei TY, Wang HP, Gao YF*. Differential activation of the calpain system involved in individualized adaptation of different fast-twitch muscles in hibernating Daurian ground squirrels, Journal of Applied Physiology, 2019 Aug. DOI:10.1152/japplphysiol.00124.2019.

11.Wei YH1, Gong LC1, Fu WW1, Xu SH, Wang Z, Zhang J, Ning E, Chang H, Wang HP, Gao YF*.Unexpected regulation pattern of the IKKβ/NF-κB/MuRF1 pathway with remarkable muscle plasticity in the Daurian ground squirrel (Spermophilus dauricus), J of Cell Physiol, 2018 Nov; 233(11):8711-8722. DOI: 10.1002/jcp.26751.

12.Wei YH1, Zhang J1, Xu SH, Peng X, Yan X, Li XY, Wang HP, Chang H, Gao YF*.Controllable oxidative stress and tissue specificity in major tissues during the torpor-arousal cycle in hibernating Daurian ground squirrels, Open Biology, 2018 Oct; 8 (10): 180068.DOI: 10.1098/rsob.180068.

13.Gao YF*, Arfat Y, Wang HP, Goswami N, Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures, Front. Physiol., 2018 March 20. 9:235. DOI: 10.3389/fphys.2018.00235.

14.魏艳红, 王慧平, 高云芳*. 冬眠哺乳动物氧化应激产生及抗氧化防御机制研究进展. 动物学杂志, 2018, 53(2): 302- 312.

15.Arfat Y, Chang H, Gao YF*. Stress-responsive microRNAs are involved in re-programming of metabolic functions in hibernators, J Cell Physiol. 2018 Apr; 233(4):2695-2704. DOI: 10.1002/jcp.26034.

16.Guo QL1, Mi X1, Sun XY1, Li XY, Fu WW, Xu SH, Wang Q, Arfat Y, Wang HP, Chang H, Gao YF*, Remarkable plasticity of Na+, K+-ATPase, Ca2+-ATPase and SERCA contributes to muscle disuse atrophy resistance in hibernating Daurian ground squirrels, Sci Rep , 2017 Sep 5;7(1):10509. DOI: 10.1038/s41598-017-10829-6.

17.Zhang J1, Li Y1, Li G1, Ma X, Wang H, Goswami N, Hinghofer-Szalkay H, Chang H*, Gao YF*, Identification of the optimal dose and calpain system regulation of tetramethylpyrazine on the prevention of skeletal muscle atrophy in hindlimb unloading rats, Biomed Pharmacother, 2017 Oct 12;96:513-523. DOI: 10.1016/j.biopha.2017.10.012.

18.Hu HX1, Du FY1, Fu WW, Jiang SF, Cao J, Xu SH, Wang HP, Chang H, Goswami N*, Gao YF*, A dramatic blood plasticity in hibernating and 14-day hindlimb unloading Daurian ground squirrels (Spermophilus dauricus), J Comp Physiol B,  2017 Jul;187(5-6):869-879. DOI: 10.1007/s00360-017-1092-7.

19.Hu NF1, Chang H1, Du B, Zhang QW, Arfat Y, Dang K, Gao YF*. Tetramethylpyrazine ameliorated disuse-induced gastrocnemius muscle atrophy in hindlimb unloading rats through suppression of Ca2+/ROS mediated apoptosis, Appl Physiol Nutr Metab, 2017, 42(2):117-127. DOI: 10.1139/apnm-2016-0363

20.Dang K1, Feng B1, Gao YF*, Hu NF, Jiang SF, Fu WW, Hinghofer-Szalkay HG. Muscle protection during hibernation of Daurian ground squirrels (Spermophilus dauricus): role of atrogin-1, MuRF1, and fiber-type transition, Can J Zool, 2016, 94 ( 9):619-629.

21.Fu WW1, Hu HX1, Dang K, Chang H, Du B, Wu X, Gao YF*, Remarkable preservation of Ca2+ homeostasis and inhibition of apoptosis contribute to anti-muscle atrophy effect in hibernating Daurian ground squirrels, Sci Rep, 2016, 6:27020.

22.党凯高云芳*,冬眠动物骨骼肌生理适应及机制的研究进展,动物学杂志,2016, 51(3):497-506.

23.Dang K1, Li YZ1, Gong LC, Xue W, Wang HP, Goswami N*, Gao YF*, Stable atrogin-1 (Fbxo32) and MuRF1 (Trim63) gene expression is involved in the protective mechanism in soleus muscle of hibernating Daurian ground squirrels (Spermophilus dauricus), Biology Open, 2016, (5): 62-71.

24.Jiang SF, Guo SP, Xue W, Wang HP, Goswami N, Gao YF*, Seasonal oxidative capacity of skeletal muscles in hibernating Daurian ground squirrels (Spermophilus dauricus), Can J Zool, 2015, 93(8):593-8.

25.Jiang SF, Gao YF*, Zhang YM, Liu K, Wang HP, Goswami N, The research on the formation mechanism of extraordinary oxidative capacity of skeletal muscle in hibernating ground squirrels (Spermophilus dauricus), Zoological Studies, 2015, 54(46):1-6.

26.Yang CX1, He Y1, Gao YF*, Wang HP, Goswami N, Changes in calpains and calpastatin in the soleus muscle of Daurian ground squirrels during hibernation, Comp Biochem Physiol A Mol Integr Physiol, 2014, 176(2014):26-31.

27.张全旺,李光月,任艳萍,高云芳*,两种脾虚证模型对小鼠骨骼肌形态和功能的影响,中国中西医结合杂志,201535(1):71-75.

28.杜蓓,高云芳*,当归对吊尾大鼠比目鱼肌收缩功能的影响,西北大学学报,201444(4):588-594.

29.Li SY1, Yang Z1, Gao YF*, Li GY, Wang HP, Hinghofer-Szalkay HG, Ligustrazine and contractile properties of soleus muscle in hindlimb-unloaded rats, Aviat Space Environ Med, 2012, 83(11):1049-1054.

30.孙小勇,高云芳*,王琦,姜山峰,郭树攀,刘坤,达乌尔黄鼠实验室饲养、繁殖及其冬眠阵,兽类学报,2012, 32(4):356-361.

31. 越,高云芳*,张少颖,张扬媚,孙小勇,王慧平,废用状态下大鼠骨骼肌再负荷对比目鱼肌Calpain活性和肌细胞膜通透性的影响,中国病理生理杂志,2012, 28(8):1500-1503.

32.张扬媚,高云芳*,废用性肌萎缩的研究进展,中华物理医学与康复杂志,2012, 34(7):550-553.

33.武雪,高云芳*,赵雪红,崔继红,川芎嗪对废用状态下大鼠骨骼肌一氧化氮合酶活性及肌纤维内Ca2+浓度的影响,中华医学杂志,2012, 92(29):2075-2077.

34.Gao YF1,*, Wang J1, Wang HP, Feng B, Dang K, Wang Q, Hinghofer-Szalkay HG, Skeletal muscle is protected from disuse in hibernating dauria ground squirrels, Comp Biochem Physiol [A], 2012, 161: 296-300.

35.姜山峰,高云芳*,模拟失重对大鼠情绪影响的初步研究,中国应用生理学杂志,2012, 28(3):205-208.

36.薛玮,高云芳*,屠晓莉,牛银波,胡琳琳,四君子汤对小鼠运动耐力与免疫功能的影响,西北大学学报,2011, 41(5):838-842.

37.冯斑,王慧平,党凯,薛玮,高云芳*,脾虚对小鼠比目鱼肌形态和功能的影响,西北大学学报,2011, 41(4):645-649.

38.Du FY, Wang J, Gao YF*, Wang HP, Wang Q, Jiang SF, Goswami N, A New Hindlimb Model for Inducing Extensor Digitorum Longus Atrophy in Rats: Tail suspension-immobilization, Aviat Space Environ Med, 2011, 82(7):689-693.

39.曹晋,高云芳*,刘坤,川芎及两种主要药效成分对废用性肌萎缩的影响,中国应用生理学杂志,2010, 26(1):109-113.

40.颜永杰,吴宽,张珏,高云芳*,谢海峰,马铃薯卷叶病毒陕西分离物(CP)的生物信息学分析,西北大学学报,2010,  40(3):473-476.

41.颜永杰,吴宽,谢海峰,高云芳*,陕西马铃薯卷叶病病原的分子生物学鉴定,西北农林科技大学学报,2010, 38(5):87-92.

42.Qin W, Gao YF*, Xue W, Zhang HX, Wang HP, Hinghofer-Szalkay HG, Effects of two traditional Chinese herbs on muscle composition after 14 days of hind limb unloading in rat, Space Med Med Eng (Beijing) (航天医学与医学工程), 2009, 22(4):235-239.

43.胡清照,高云芳*,曹晋,不同浓度四君子汤对尾部悬吊大鼠比目鱼肌肌萎缩的影响,航天医学与医学工程,2009, 22(1):9-12.

44.张海祥,何志仙,高云芳*,一种复方制剂对尾部悬吊大鼠比目鱼肌mATP酶活性升高及肌萎缩的影响,中国应用生理学杂志,2008, 24(3):367-371.

45.Yunfang Gao, Nandu Goswam, Erik Grasser, Andreas Rössler, Erich Stöger,Günther Schwaberger, Helmut G. Hinghofer-Szalkay*Radix Astragali and orthostatic response: A double-masked crossover study, Aviat Space Environ Med, 2008, 79(2):94-98.

46.Zhang H, He Z, Gao Y*, Hinghofer-Szalkay HG, Fan X, Muscle Composition After 14-Day Hindlimb Unloading in Rats: Effects of Two Herbal Compounds, Aviat Space Environ Med, 2007, 78(10):926-931.

47.王琦,高云芳*,樊小力,尾部悬吊对达乌尔黄鼠(Spermophilus dauricus)比目鱼肌形态及 mATP酶活性的影响,动物学报, 200753(1):116-122.

48.王珺,高云芳*,姚洋,不同剂量四君子汤对脾虚证小鼠消化和免疫功能的影响,中草药,2007, 38(4):558-564.

49.何志仙,周华凤,高云芳,骨骼肌萎缩中药防护的研究进展,西北药学杂志,2007, 22(5):286-287.

50.高云芳,王慧平,李保国,秦岭野生雌性川金丝猴粪便睾酮水平与邀配频次的季节性变化,动物学报,2007, 53(5):783-790.

51.王琦,何志仙,高云芳,pH值对应用肌球蛋白ATP酶法进行梭内肌纤维分型的影响,陕西理工学院学报,2006221):83-85.

52.高云芳,改革教学方法,多途径提高生理学本科教学水平,高教发展研究,20061(总86期),54-55.

53.高云芳,何志仙,樊小力*,吴苏娣,宋新艾,氯化胆碱对尾吊大鼠比目鱼肌肌萎缩对抗效果的观察,航天医学与医学工程,2006, 19(5):324-328.

54.党凯,王琦,张海祥,高云芳*,幼龄、亚成年、成年达乌尔黄鼠比目鱼肌III型肌纤维的比例与脏器指数的比较,动物学研究,2006, 27(6):626-630.

55.高云芳,樊小力*,三种活血类中药对蟾蜍离体单一肌梭传入放电的影响, 航天医学与医学工程,2005, 18(1):16-18.

56.高云芳,何志仙,樊小力*,胡琳琳,宋新艾,pH值对应用mATP酶法进行梭外肌纤维分型的影响,西北大学学报,2005, 35(1):76-78.

57.高云芳*,张小燕,张富昌,秦巴山区生态环境对当地居民毛发中微量元素的影响,应用生态学报,2005, 16(2):355-359.

58.王慧平,高云芳*,张新利,李保国,川金丝猴粪尿中类固醇性激素抽提方法比较,兽类学报,2005, 25(3):297-301.

59.高云芳,樊小力*,何志仙,吴苏娣,宋新艾,川芎嗪和黄芪对尾部悬吊大鼠比目鱼肌肌球蛋白ATP酶活性及肌萎缩的影响,航天医学与医学工程,2005, 18(4):262-266.

60.高云芳*,高更更,白绪祥,张新利,陈超,李保国,雌性川金丝猴尿液中雌二醇与孕酮水平的季节性变化,西北大学学报,2005, 35(5):592-596.

61.胡琳琳,高云芳*,何志仙,三种脾虚证模型小鼠消化吸收功能改变的比较研究,中国中西医结合杂志,2005, 25(9):813-816.

62.何志仙,高云芳*,胡琳琳,幼成年大白鼠和小白鼠比目鱼肌中型肌纤维的比例与脏器指数的比较,动物学研究,2005, 26(3):322-327.

63.高云芳,秦岭川金丝猴对高海拔栖息地的某些生理适应,应用生态学报,2004, 15(2):331-334.

64.高云芳*,高更更,曹永汉,常秀云,川金丝猴野生种群与人工种群体毛10种微量元素的含量及比较,动物学研究,2004, 25(2):181-184.

65.高云芳,王慧平,李保国,秦岭山中的川金丝猴,生物学通报,2004, 39(10):10-11.

66.Gao Yunfang, Fan Xiaoli*, Effect of Angelica Sinensis on afferent discharge of single muscle spindle in toads, Academic Journal of Xi’an Jiaotong University, 2004,16(2):178-180.

67.Wang HuiPing, Chia L. Tan, Gao Yunfang*, Li Baoguo. A takeover of resident-male in the Sichuan snub-nosed monkey Rhinopithecus roxellanae in Qinling Mountains, 动物学报,2004, 50(5):859-862.

68.高云芳*,王慧平,王亚洲,王丹,朱晓东,四君子汤对脾虚证小鼠血象及胃酸分泌的影响,西北大学学报,2003, 33(2):213-216.

69.高云芳,陈超,李保国,张新利,卢新明,高更更,白绪祥,贾康社,川金丝猴尿液中睾酮水平的季节性变化,动物学报,2003, 49(3):393-398.

70.闫继东,高云芳*,水蛭粉针剂抗凝抗栓作用的初步研究,西北大学学报,2001,31:112-114.

71.高云芳*,陈超,梁固城,张海祥,桔梗总皂甙对大鼠高脂血症的影响,中草药,2000,31(10):764-765.

72.闫继东,高云芳*,桔梗总皂甙止咳作用初步观察,应用生理学杂志,2000, 16(3):150

73.阎锡海,高云芳,延安近郊达乌尔鼠兔种群数量与危害的调查,西北大学学报,1999, 29(6):601-605.

74.阎锡海,高云芳,啮齿动物对延安地区林区危害的调查,西北大学学报,1998, 28(6):527-530.

75.高云芳,蒙世杰,刘诗峰,川金丝猴血象及血液生物化学指标的研究,动物学报,1998, 44(2):190-194.

76.高云芳,烟碱和吗啡对豚鼠小肠电与张力的影响,西北大学学报,1998, 28(3):255-258.

77.蒙世杰,米钧,高云芳*,川金丝猴血清蛋白及几种同工酶的研究,中国灵长类研究通讯,1998, 7(1-2):16-27.

78.高云芳,富硒茶对小肠电活动与小肠运动的影响,陕西师大学报1998, 26(3):121-122.

79.高云芳徐振武,中国大鲵小肠电和小肠运动的神经控制,陕西师大学报1997, 25(3):82-84.

80.高云芳,袁武,体育系学生苯硫脲尝味能力与血型的研究,陕西师大学报1995, 23(4):74-77.

81.刘诗峰,高云芳,川金丝猴正常血清蛋白及两种同功酶的电泳分析,灵长类研究与保护,中国林业出版社,1995, 379-383.

82.刘诗峰,高云芳,秦岭川金丝猴种群分布与数量变动原因的分析,灵长类研究与保护,中国林业出版社,1995, 191-196.

83.高云芳,刘诗峰,中国大鲵离体小肠的电活动与收缩活动,西北大学学报,1995, 25(5):525-528.

84.Gao Yunfang, Liu Shifeng, Physiological adaptations of golden monkeys to high altitude habitat in the Qinling Mountains, Asian Primates, 1995, 5(2):17-19.

85.Fan Peizhong, Gao Yunfang and Liu Shifeng. Commonly encountered diseases in golden monkeys, and their prevention, under captive conditions, Asian Primates, 1993, 2(4):11-13.

86.高云芳,刘诗峰,曹永汉等,川金丝猴异常心电图1例分析,动物学研究,1994, 15(3):28-38.

87.高云芳,苏生珍,豚鼠离体小肠电活动与机械收缩,陕西师大学报1994, 22(3):60-63.

88.高云芳,苏生珍,席长暄,几种离子通道阻断剂对豚鼠离体小肠电活动与收缩活动的影响,西北大学学报,1991, 21(3):93-98.


获奖经历:

1.2017年获陕西省高等学校科学技术二等奖,获奖项目名称:活血化瘀类与补益类药物在抗废用性肌萎缩中的应用研究,项目编号17N09,主持。

2. 2009年荣获陕西省科学技术进步一等奖,获奖项目名称:秦岭金丝猴种群稳定机制研究,项目编号09-1-28-R6,参与。