个人简介

惠文利，2001年毕业于天津工业大学材料学院，获高分子材料科学与工程学士学位。2013年毕业于西北大学生命科学学院，获生物化学与分子生物学专业博士学位。在读博士期间于在香港城市大学机械及生物医学工程学系交流学习一年。主要从事纳米材料及其在生物医学领域的应用研究，研究成果以主要参与人获陕西省科学技术一等奖一项，相关研究在一区刊物发表论文3篇。主持国家自然科学基金项目两项，主持陕西省教育厅专项科研计划项目一项。多次参与国家“863”计划项目、“973”计划项目、国家科技重大专项、国家重大传染病专项等项目的申请与研发工作。 通信地址：西北大学生命科学学院，西安市太白北路229号，邮编710069

承担的科研项目

主持项目：
1.国家自然科学基金面上项目：基于“微流控PCR-纳米金磁微粒层析法” POCT分子诊断技术平台的构筑及临床试验研究（31771083），2018.1-2021.12，主持
2.国家自然科学基金青年项目：适用于POCT免疫层析技术纳米金磁微粒的构筑及其机理研究”（31200749），主持
参与项目：
1.国家科技重大专项“重大新药创制” GoldMag金磁微粒标记CYP2C19基因分型试纸条开发及其在硫酸氯吡格雷个体化临床用药中的应用
2.国家自然科学基金面上项目：核酸适配体-纳米金磁微粒复合探针对ARMS-PCR产物捕获及MTHFRC677T 基因分型层析检测新方法研究
3.国家自然科学基金面上项目：PSCA适配子-tBID-Fe3O4双功能MR分子探针对前列腺癌及其骨转移靶向诊疗作用的研究
4.国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项 ：基于金磁颗粒免疫层析及比浊免疫技术的系列快速检测试剂的研制

主要研究成果

论文发表：(通讯作者，#共同第一作者)
（1）Chao Zhang, Xiaonan Liu,Yao Yao, Kewu Liu, Wenli Hui, Juanli Zhu, Yaling Dou, Kai Hua, Mingli Peng, Zuankai Wang, Alphonsus J.M. Vermorken, and Yali Cui. Genotyping of Multiple Clinical Samples with a Combined Direct PCR and Magnetic Lateral Flow Assay iScience 2018.
（2）Xiaonan Liu, Chao Zhang, Kewu Liu, Han Wang, Chaoxia Lu, Hang Li, Kai Hua, Juanli Zhu,Wenli Hui, Yali Cui, and Xue Zhang. Multiple SNPs Detection Based on Lateral Flow Assay for Phenylketonuria Diagnostic.Anal.Chem. 2018.
（3）Xiaonan Liu ,Chao Zhang, Mengye Zhao Kewu Liu, Hang Li Ningning Li,Linlin Gao, Xuemin Yang,Ting Ma, Juanli Zhu,Wenli Hui ,Kai Hua Yali Cui. A direct isothermal amplification system adapted for rapid SNP genotyping of multifarious sample types. Biosensors and Bioelectronics. 2018
（4）XianYing Li, Chao Zhang , QinLu Zhang, JuanLi Zhu, Qian Liu, MingWei Chen, XueMin Yang, WenLi Hui ,YaLi Cui Sensitive genotyping of mutations in the EGFR gene from NSCLC patients using PCR-GoldMag lateral flow device. Scientific Reports .2017.
（5）Wenli Hui, Sinong Zhang,Chao Zhang,a Yinsheng Wan, Juanli Zhu,Gang Zhao, Songdi Wu, Dujuan Xi, Qinlu Zhang, Ningning Li and Yali Cui  A Novel Lateral Flow Assay Based on GoldMag Nanoparticles and Its Clinical Applications for Genotyping of MTHFR C677T Polymorphisms. Nanoscale. 2016
（6）Ting Lian, Wenli Hui, XianYing LI, Chao Zhang, Juanli Zhu, Rui Li, YinSheng Wan and Yali Cui Apolipoprotein E genotyping using PCR-GoldMag lateral flow assay and its clinical applications. Molecular medicine reports. 2016
（7）Mei Zhang,Yanhua Zhao,Li Yan, Raoul Peltier, Wenli Hui, Xi Yao, Yali Cui, Xianfeng Chen,Hongyan Sun, and Zuankai Wang, Interfacial Engineering of Bimetallic Ag/Pt Nanoparticles on Reduced Graphene Oxide Matrix for Enhanced Antimicrobial Activity. Acs Applied Materials & Interfaces. 2016
（8）XiaoWen. Huang，Wenli Hui, Chonglei. Hao, Yali. Cui, Zuankai. Wang. On-site formation of emulsions by controlled air plugs. Small. 2014
（9）D. Yang, J. Ma, M. Gao, Y. Luo, W. L. Hui， M. Peng, C. Chen, Z. Wang, Y. Cui. Suppression of composite nanoparticle aggregation through steric stabilization and ligand exchange for colorimetric protein detection. RSC Advances, 2013
（10）Chao Zhang, Yao Yao, Juan Li Zhu, Si Nong Zhang1, Shan-Shan Zhang1, Hua Wei1,
WenLi Hui , YaLi Cui. Establishment and application of a real-time loop-mediated
isothermal amplification system for the detection of CYP2C19 polymorphisms. Scientific Report 2016.
（11）Xinxing Li, Qinlu Zhang, Peng Hou, Mingwei Chen, Wenli Hui, Zhiyi Luo，Hong Li, Qin Li and Yali Cui. Gold magnetic nanoparticle conjugate-based lateral flow assay for the detection of IgM class antibodies related to TORCH infections. International Journal of Molecular Medicine.2015
（12）Dong Yang, Jianzhong Ma, Qinlu Zhang, Ningning Li, Jiangcun Yang, Paul Ananda Raju,
Mingli Peng, Yanling Luo, Wenli Hui,Chao Chen,and Yali Cui. Polyelectrolyte-Coated Gold Magnetic Nanoparticles for Immunoassay Development: Toward Point of Care Diagnostics for Syphilis Screening. Analytical Chemistry.2013
（13）Dong Yang, Jianzhong Ma, Min Gao, Mingli Peng, Yanling Luo,Wenli Hui,Chao Chen, Zuankai Wang and Yali Cui. Suppression of composite nanoparticle aggregation through steric stabilization and ligand exchange for colorimetric protein detection. RSC Advances. 2013