个人简介

教育/工作经历
1997-2001 西北大学生命科学学院 生物化学专业 本科
2001-2004 首都师范大学细胞生物学专业 硕士
2004-2007 中国农业大学微生物学专业 博士
2007-2013 美国华盛顿大学病理学系 博士后
2013-2016 江南大学医学院 副教授，硕士生导师
2017-至今 西北大学生命科学学院 教授，博士生导师
主要研究方向：肿瘤细胞生物学
骨髓微环境，是支持和调节造血干/祖细胞生长发育的内环境，包括骨髓基质细胞、细胞外基质和造血因子等。造血干细胞和造血微环境通常被比拟为“种子”和“土壤”。骨髓基质细胞在促进造血干细胞生成血细胞的各个环节中如静止、分化、增殖、成熟、凋亡和耐药等都起着十分重要的作用。本课题组利用多组学技术挖掘骨髓微环境中的利好因子，结合细胞模型、小鼠模型、临床样本等，研究骨髓微环境中这些利好因子的生物学功能以及分子调控机制等，为阐明骨髓微环境对造血干细胞的命运决定提供理论基础。
通信地址：西北大学生命科学学院，西安市太白北路229号，邮编：710069

承担的科研项目

1）国家自然科学基金面上项目：骨髓基质细胞中β4GALT1介导高危MDS克隆细胞增殖和耐药的机制研究，2018-2021
2）国家自然科学基金面上项目：转录因子TWIST1 参与骨髓增生异常综合征（MDS）中DNA 甲基化作用机制的研究，2015-2018
3）国家自然科学基金青年项目: 由N-乙酰氨基葡萄糖转移酶-III（MGAT3）催化的平分型N-糖链在骨髓造血微环境中的功能研究 2015-2017
4） 江苏省自然科学基金青年项目：β1,4-半乳糖转移酶1（β4GALT1）在骨髓造血微环境中的功能研究 20万 2014-2017
5）微环境对肿瘤细胞命运决定的研究 中央高校基本科研业务费专项重点项目 2016-2019
6）血液肿瘤共培养细胞模型的组学分析 留学归国人员基金 2014-2016
7）Transplantation and iron overload in MDS 美国东南密歇根社会基金 2009-2011

主要研究成果

1. Xingchen Pang, Yi Wang, Zengqi Tan, Jia Guo, Feng Guan, Xiang Li. Altered susceptibility to apoptosis and N‑glycan profiles of hematopoietic KG1a cells following co‑culture with bone marrow‑derived stromal cells under hypoxic conditions. Oncol Rep. 2018 Sep;40(3):1477-1486.
2. Xingchen Pang, Hongjiao Li, Feng Guan, Xiang Li. Multiple Roles of Glycans in Hematological Malignancies. Front Oncol. 2018 Sep 6;8:364.
3. Zengqi Tan, Chenxin Wang, Xiang Li, Feng Guan. Bisecting N-Acetylglucosamine Structures Inhibit Hypoxia-Induced Epithelial-Mesenchymal Transition in Breast Cancer Cells. Front Physiol. 2018 Mar 9;9:210.
4. Dinghao Zhuo D, Xiang Li, Feng Guan. Biological Roles of Aberrantly Expressed Glycosphingolipids and Related Enzymes in Human Cancer Development and Progression. Front Physiol. 2018 May 3;9:466.
5. Jia Guo, Changmei Liu, Xiaoman Zhou, Xiaoqiang Xu, Linhong Deng, Xiang Li *, Feng Guan *. Conditioned Medium from Malignant Breast Cancer Cells Induces an EMT-Like Phenotype and an Altered N-Glycan Profile in Normal Epithelial MCF10A Cells. Int J Mol Sci. 2017 Aug 1;18(8).
6. Xiang Li, Ting Wan, Sijie Zhang, Dongliang Li, Xiaofeng Han. Quantitative proteomic analysis and comparison of two bone marrow stromal cell lines using the SILAC method. Exp Hematol. 2016;44(11):1059-1071.
7. Xiang Li, Dongliang Li, Ganglong Yang, Zengqi Tan, Zhaohui Huang. Identification of aberrantly expressed glycans by lectin microarray and mass spectrum analysis in gastric cancer. Oncotarget. 2016;7(52):87284-87300.
8. Xiang Li, Xin Wang, Zengqi Tan, Si Chen, Feng Guan. Role of glycans in cancer cells undergoing epithelial-mesenchymal transition. Frontiers in Oncology. 2016.00033. eCollection.
9. Xiang Li *, Shiwei Li, Mize Lu, Guohua Yang, Yunfeng Shen, Xin Zhou* Proteomic profiling of iron overload-induced human hepatic cells reveals activation of TLR2-mediated inflammatory response. Molecules. 2016,21:322
10.Feng Guan, Xiang Li, Jia Guo, Ganglong Yang, Xiang Li*. Ganglioside-magnetosome complex formation enhances uptake of gangliosides by cells. International Journal of Nanomedicine. 2015:10, 1-12.
11. Shiwei Li, Changmei Liu, Jia Guo, A. Mario Marcondes, Joachim Deeg, Xiang Li*, Feng Guan*. Iron overload induced by ferric ammonium citrate triggers reactive oxygen species-mediated apoptosis via both extrinsic and intrinsic pathways in human hepatic cells. Human and Experimental Toxicology. 2015. Jul. 29 (co-corresponding author)
12. Xiang Li, Dongliang Li, Xingchen Pang, Joachim Deeg, Feng Guan. Quantitative analysis of glycans, related genes, and proteins in two human bone marrow stromal cell lines using an integrated strategy. Exp Hematol. 2015, 43(9):760-769.
13. Xiang Li, Joachim Deeg. Murine xenogeneic models of myedysplastic syndrome (MDS): An essential role for stroma cell. Exp Hematol. 2014; 42 (1): 4-10.
14. Xiang Li#, Feng Xu#, Karoopongse Ekapun, Mario Marcondes, Kayoung Lee, Joachim Deeg. Allogeneic transplantation, fas signaling, and dysregulation of hepcidin. Biol Blood Marrow Transplant. 2013 Aug; 19(8):1210-9. (Co-first author)
15. Xiang Li, Mario Marcondes , Tobias Ragoczy , Joachim Deeg . Effect of intravenous coadministration of human stroma cell lines on engraftment of long-term repopulating clonal myelodysplastic syndrome cells in immunodeficient mice. Blood Cancer J. 2013 Apr 26;3:e113.
16.Xiang Li, Feng Xu, John Byon, Thalia Papayannopoulou, H.Joachim Deeg, A. Mario Marcondes. Transcriptional regulation of miR-10a/b by TWIST-1 in myelodysplastic syndromes. Haematologica. 2013 Mar; 98(3):414-9.
17.Xiang Li, Mario Marcondes, Ted Gooley, Joachim Deeg. The helix-loop-helix transcription factor TWIST is dysregulated in Myelodysplastic Syndromes. Blood. 2010 Sep 30; 116(13): 2304-14.
18.Xiang Li, Wei Jiang, Jianbo Sun, Guili Wang, Feng Guan, Ying Li. Purified and Sterilized Magnetosomes from Magnetospirillum gryphiswaildense MSR-1 were not toxic for mouse fibroblasts in vitro. Lett Appl Microbiol. 2007 Jul; 45(1):75-81.
19.Xiang Li, Bin Wang, Huali Jin, Wei Jiang, Jiesheng Tian, Feng Guan,Ying Li. Bacterial Magnetic Particles (BMPs)-PEI as a novel and efficient non-viral gene delivery system. J Gene Med. 2007;9(8):679-90.
20.Mario Marcondes, Xiang Li, LauraTabellini, Matthias Bartenstain, Joachim Deeg. Inhibition of IL-32 activation by α1 anti-trypsin (AAT-1) is associated with suppression of alloreactivity and increased survival in a murine minor antigen disparate transplant model. Blood. 2011 Nov 3; 118 (18): 5031-9.
21.Mario Marcondes, Xiang Li, Ted Gooley, Joachim Deeg. Identification of DJ-1/Park-7 as a determinant of stroma-dependent and TNF{alpha}-induced apoptosis in MDS by using mass spectrometry and phosphopetide analysis. Blood. 2010 Mar 11; 115(10):1993-2002.