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陈卓玥
发布时间:2023-03-29      作者:    点击:[]    分享到:

个人简介

陈卓玥,女,1987年生,汉族,陕西兴平人,中共党员。研究方向为组织工程与再生医学。

教育工作经历:

2023.02- 今 ,西北大学生命科学与医学部 副教授

2019.06-2023.01 ,西北大学生命科学与医学部 讲师

2019.11-2022.01,耶鲁大学病理学系 访问学者

2017.01-2019.06 西北大学生命科学与医学部 师资博士后

2012.09-2016.12  西北大学生命科学学院 细胞生物学 博士

2009.09-2012.06  西南交通大学  生物医学工程 硕士(推免)

2005.09-2009.06  重庆大学  生物工程 本科


主持的科研项目

(1)国家自然科学基金面上项目(新型RADA16-类人胶原融合材料的制备及其快速止血和促进组织修复性能的研究,2022.1-2025.12,32171329,58万)

(2)国家自然科学基金青年项目(重组类人胶原-骨形成蛋白融合材料的制备及其诱导成骨作用的研究,2018.1-2020.12,21706212,26万)

(3)中国博士后科学基金面上项目(基因重组类人胶原蛋白作为骨形成蛋白缓释载体的研究,2018.1-2019.6,2017M623228,5万)

(4)陕西省教育厅自然科学专项课题(新型类弹性蛋白-蚕丝纤维复合材料制备的研究,2016.7-2018.12,16JK2245,2万)


主要研究成果

第一或通讯作者文章

(1)Yayuan Guo, Zeyu Hu, Jilong Chen,Zhen Zhang, Qian Liu, Juan Li, Jiaojiao Yang, Zihan Ma, Jing Zhao, Jingyan Hu, Jiawei Wu, Zhuoyue Chen. Injectable TG-linked recombinant human collagen hydrogel loaded with bFGF for rat cranial defect repair. Int J Biol Macromol., 2023, 236(2023):123864 (通讯作者,一区,IF=8.025).

(2)Yayuan Guo, Nanqiong Cheng, Hongxiao Sun, Jianing Hou, Yuchen Zhang, Du Wang, Wei Zhang, Zhuoyue Chen. Advances in the development and optimization strategies of the hemostatic biomaterials. Front Bioeng Biotechnol., 2022; 10: 1062676. (通讯作者,二区,IF=6.064).

(3)Zhuoyue Chen; Zhen Zhang; Zhaoyue Wang; Jiawei Wu; Yihang Wang; He Si; Xin Xie; Lijun Shang*; Daidi Fan*; Fulin Chen*; Fabricating a novel HLC-hBMP2 fusion protein for the treatment of bone defects, Journal of Controlled Release, 2021, 329: 270-285 (一作,一区,IF=9.776).

(4)Zhuoyue Chen; Qiang Zhang; Hongmin Li; Qi Wei; Xin Zhao*; Fulin Chen*, Elastin-like polypeptide modified silk fibroin porous scaffold promotes osteochondral repair, Bioactive Materials, 2021, 16(3): 589-601 (一作,一区,IF=14.593,他引24).

(5)Yayuan Guo, Zhengyue Bian, Qian Xu, Xiaomin Wen, Juan Kang, Shuai Lin, Xue Wang, Zhaoxiang Mi, Jihong Cui, Zhen Zhang, Zhuoyue Chen *, Fulin Chen*. Novel tissue-engineered skin equivalent from recombinant human collagen hydrogel and fibroblasts facilitated full-thickness skin defect repair in a mouse model. Mater Sci Eng C Mater Biol Appl. 2021, 130:112469 (共同通讯,一区,IF=7.328).

(6)Zhuoyue Chen; Daidi Fan*; Lijun Shang*; Exploring the potential of the recombinant human collagens for biomedical and clinical applications: a short review, Biomedical Material, 2020, 16: 012001(一作,二区,IF=3.715).

(7) Zhuoyue Chen; Zhen Zhang; Xiaoxuan Ma; Zhiguang Duan; Junfeng Hui; Chenhui Zhu; Donggang Zhang; Daidi Fan*; Lijun Shang*; Fulin Chen*; Newly Designed Human-Like Collagen to Maximize Sensitive Release of BMP-2 for Remarkable Repairing of Bone Defects, Biomolecules, 2019, 9: 450 (一作,二区,IF=4.082,他引14).

(8) Rongrong Wang, Zhaoyue Wang, Yayuan Guo, Hongmin Li, Zhuoyue Chen*, Design of a RADA16-based self-assembling peptide nanofiber scaffold for biomedical applications, Journal of biomaterials science-polymer edition, 2019, 30(9): 713-736 (通讯作者,二区,IF=2.69,他引19).

(9) Zhuoyue Chen, Zhen Zhang, Juantao Feng, Yayuan Guo, Yuan Yu, Jihong Cui, Hongmin Li, Lijun Shang*, The influence of Mussel-Derived Bioactive BMP-2 decorated PLA on MSCs behavior in vitro and verification with osteogenicity at ectopic sites in vivo, ACS Appl Mater Inter, 2018, 10: 11961-71 (一作,一区,IF=8.456,他引16)

(10) Zhuoyue Chen#, Yue Song#, Jing Zhang, Wei Liu, Jihong Cui*, Hongmin Li, Fulin Chen, Laminated electrospun nHA/PHB-composite scaffolds mimicking bone extracellular matrix for bone tissue engineering, Materials Science & Engineering C Materials for Biological Applications, 2017, 72(1):341-351 (共一,一区,IF=5.08,他引45)

(11) Zhuoyue Chen#, Jing Wei#, Jun Zhu, Wei Liu, Jihong Cui, Hongmin Li, Fulin Chen*, Chm-1 gene-modified bone marrow mesenchymal stem cells maintain the chondrogenic phenotype of tissue-engineered cartilage, Stem Cell Research & Therapy, 2016, 7(1): 70 (共一,一区,IF=4.211,他引10)

(12) Zhuoyue Chen*, Quanli Li, Jialong Chen, Rifang Luo, Manfred F. Maitz, Nan Huang*, Immobilization of serum albumin and peptide aptamer for EPC on polydopamine coated titanium surface for enhanced in-situ self-endothelialization, Materials Science & Engineering C Materials for Biological Applications, 2016, 60(1): 219-229 (一作通讯,二区,IF=4.164,他引20)


非第一或通讯作者文章

(1) Yayuan Guo, Bing Xu, Yihang Wang, Yan Li, He Si, Xiaoyan Zheng, Zhuoyue Chen, Fulin Chen*, Daidi Fan*. Dramatic promotion of wound healing using a recombinant human-like collagen and bFGF cross-linked hydrogel by transglutaminase. J Biomater Sci Polym Ed. 2019, 30(17):1591-160 (七作,二区,IF=2.69)

(2) Jialong Chen, Juan Wang, Pengkai Qi, Xin Li, Baolong Ma, Zhuoyue Chen, Quanli Li, Yuancong Zhao, Kaiqin Xiong, Manfred F. Maitz, Nan Huang*, Biocompatibilitystudies of poly(ethylene glycol)-modified titanium for cardiovascular devices, Journal of Bioactive and Compatible Polymers, 2012, 27(6): 565-584 (六作,二区,IF=2.207)

(3) Jialong Chen, Cheng Chen, Zhuoyue Chen, Junying Chen, Quanli Li*, Nan Huang*, Collagen/heparin coating on titanium surface improves the biocompatibility of titanium applied as a blood-contacting biomaterial, J Biomed Mater Res A, 2010, 95(2): 341-349 (三作,二区,IF=3.044,他引52).

注:他引超过10次以上作了标注。

发明专利

(1)黄楠,陈卓玥,陈佳龙,李全利,王进,冷永祥,杨苹,陈俊英,孙鸿,吴熹,一种心血管植入装置表面固定多肽适配子的方法,2011.6.8,中国,CN201010589076.4

(2)黄楠,陈佳龙,王娟,李全利,曹建军,陈卓玥,熊开琴,孙鸿,杨苹,冷永祥,陈俊英,王进,一种用于冠心病检测和治疗的纳米磁性粒子的制备方法,2011.6.8,中国,CN201110000852.7

(3)陈富林,陈卓玥,李红民,谢鑫,崔继红,余源,张婧,一种类弹性蛋白蚕丝纤维多孔复合材料及其应用,2019.6.4,中国,ZL 201710024586.9

(4)陈卓玥,陈富林,侯增淼,梁强,赵金礼,一种RHC-(RADA)4融合蛋白,2022.11.1,中国,ZL 201910375539.8


获得的表彰

1. 第五届全国大学生生命科学创新创业大赛一等奖(指导教师) 2020

2. 国家级大学生创新创业训练(指导教师)2019

3. iGEM大赛铜奖(指导教师)2018

4. 第三届全国大学生生命科学创新创业大赛三等奖(指导教师)2017

5. 陕西省细胞生物学学会青年优秀论文二等奖,2018


与企业合作研究

1. 与陕西慧康生物科技有限责任公司的共同研发成果申报了一项专利《一种RHC-(RADA)4融合蛋白》,此外,该成果还在积极申报开发为医疗器械产品。

2. 与江苏地韵医疗科技有限公司签订了横向课题一项(软骨诱导性多孔胶原支架的开发,20万,2019/3-至今)