个人简介

副教授，硕士研究生导师

E-mail：zishengguo@nwu.edu.cn；

通讯地址：西北大学生命科学学院；西安市太白北路229#；710069；

主要研究方向：

病原微生物耐药机理及“新型抑菌物质”探寻；

地质微生物与元素循环及环境微生物开发利用；

教育及工作经历：

1. 西北大学，生命科学学院，教师；

2. 西北大学，化学生物学，博士后；

3. UC Berkeley, Microbial Biology, Visiting Postdoctoral Scholar;

4. 华中农业大学，病原微生物与免疫学，博士；

5. 西北农林科技大学，生物技术专业，学士；

主要研究成果

发表论文：

1. John Zupan#, Zisheng Guo#, Trevor Biddle, Patricia Zambryski. Agrobacterium tumefaciens Growth Pole Ring Protein: C Terminus and Internal Apolipoprotein Homologous Domains Are Essential for Function and Subcellular Localization. mBio. 2021, 18; 12(3): e00764-21. doi: 10.1128/mBio.00764-21. PMID: 34006657.  

2. Xian Li, Tiantian Zhang, Ziwei Liu, Meng Jiao, Qian Li, Martin Gand, Kexin Zhu, Yibing Qiao, Wushuang Bai, Zisheng Guo*,Bin Li, Yiran Wang, Jing Dong, Binglin Li*. Machine learning analysis of pre-culture effects on rate-limiting steps in volatile compound dynamics of Mead. Food Chem X, 2025 Feb 25;26:102313. doi: 10.1016/j.fochx.2025.102313. PMID: 40109907.

3. Guangming Zhang#, Zisheng Guo#, Shuo Liu, Qiaoli Yang, Yiming Yuan, Ke Guo, Weixiao Wang, Haina Wang, Jie Feng, Wei Chen, Yanmei Sun, Shiwei Wang. Bacteriophage application in inhibiting corrosion- producing bacteria. BMC Microbiology, 2025 Apr 23;25(1):241. doi: 10.1186/s12866-025-03952-2. PMID: 40269689.  

4. Shuo Liu, Yun Xie, Chenyu Li, Guangming Zhang, Xin Wang, Huarui Zhao, Hui Chang, Baochao Hou, Wei-Lian Hung, Jian He, Baolei Li, Zisheng Guo*, Yanmei Sun*, Shiwei Wang*. Anti-osteoporosis activity and mechanism analyses of Limosilactobacillus fermentum YSC5001 from Chinese traditional dairy products. Journal of Functional Foods, 130(2025), 106905. Volume 130, July 2025, 106905, https://doi.org/10.1016/j.jff.2025.106905.

5. Jiale Wang†, Jiawei Guan†, Xingyu Ma, Dongyang Zhao, Yongqiang Han, Dongdong Guo, Jialin Bai, Zisheng Guo* and Xiaojun Zhang*. Artemisia argyi-Mediated Synthesis of Monodisperse Silver Nanoparticles as Components of Bioactive Nanofibrous Dressings with Dual Antibacterial and Regenerative Functions. Journal of Functional Biomaterials. 2025, 16, 236.

6. Biwen Ren, Yiwei Li, Pai Wang, Jiao Chen, Zisheng Guo#, Xilang Jin, Mengyao She#. Constructing ratiometric enhanced probes via regulating recognition moiety, for bacteriostasis, nanofibrous film detection, and Hg2+ imaging in living systems. Dyes and Pigments, 223(2024): 111929.  

7. Zisheng Guo#, Bin Zhu#, Jia Guo#, Gongting Wang, Meng Li, Qiaoli Yang, Liping Wang, Yue Fei, Shiwei Wang, Tian Yu*, Yanmei Sun*. Impact of selenium on rhizosphere microbiome of a hyperaccumulation plant Cardamine violifolia. Environmental Science and Pollution Research International. 2022 Feb 4. doi: 10.1007/s11356-022-18974-w. DOI: 10.1007/s11356-022-18974-w, PMID: 35122198.

8. Qingyun Zhang, Zhulin Wang, Zhichao Qin, Binglin Li*, Zisheng Guo*. Effect of Pretreatment of Activated Carbon on Iron Oxide-Loaded Catalysts to Significantly Enhance Production of Sebacic Acid from Castor Oil. Molecules, 2024 Sep 23, 29(18): 4504. doi: 10.3390/molecules29184504.  

9. Lang Gao#, Zisheng Guo#, Yue Wang, Yulu Wang, Kerong Wang, Bo Li*, Lixin Shen*, The Two-Operon-Coded ABC Transporter Complex FpvWXYZCDEF is Required for Pseudomonas aeruginosa Growth and Virulence Under Iron-Limiting Conditions. Journal of Membrane Biology, 2018.02, 251(1): 91~104.

10. Ying Liang#, Zisheng Guo#, Lang Gao, Qianqian Guo, Liyue Wang, Yan Han, Kangmin Duan*, Lixin Shen*, The role of the temperature-regulated acyltransferase (PA3242) on growth, antibiotic resistance and virulence in Pseudomonas aeruginosa. Microbial Pathogenesis, 2016, 101:126~135.

11. Yanmei Sun, Dongmei Xu, Guangming Zhang, Wenjing Wu, Yu Ma, Weina Kong, Zisheng Guo, Bentao Xiong, Shiwei Wang, Xuejin Zhao. Wild-type Escherichia coli Nissle 1917 improves hyperuricemia by anaerobically degrading uric acid and maintaining gut microbiota profile of mice. Journal of Functional Foods, Pub 11(2024)105935.

12. Chong Wang, Li Wang, Chongbin Bai, Mingpeng Wang, Tao Ma, Honglin Ma, Guangming Zhang, Weiwei Wang, Zisheng Guo, Yanmei Sun*, Shiwei Wang*. Identification of the key factors influencing biodeterioration of open-air cultural heritage in the temperate climate zone of China. International Biodeterioration & Biodegradation, 2024-11-16, DOI:10.1016/j.ibiod.2024.105954.  

13. Quanquan Li, Mingjie Wen, Yusen Zhang, Zisheng Guo, Xue Bai, Jinxi Song, Pingliu, Yaoyu Wang, Jianli Li. Multiple fluorescence response behaviors towards antibiotics and bacteria based on a highly stable Cd-MOF. Journal of Hazardous Materials. 2021, 11; 423(Pt B):127132. DOI: 10.1016/j.jhazmat.2021.127132. PMID: 3453765

14. Fei Yang, Xiuzhu Huo, Xiaoyu Fu, Xiaoyu Wang, Ye Liu, Zisheng Guo, Jiao Chen, Mengyao She, Jianli Li. Ratiometric Fluorescent Sensors for Real-Time Monitoring Cellular Autophagy Levels during Diabetic Wound Healing. ACS Sensors, 2025 Apr 11. doi: 10.1021/acssensors.5c00198. PMID: 40215171.

15. Pansong Zhang, Qiao Guo, Zhihua Wei, Qin Yang, Zisheng Guo, Lixin Shen, Kangmin Duan, and Lin Chen. Baicalin Represses Type Three Secretion System of Pseudomonas aeruginosa through PQS System. Molecules, 2021, 26(6), 1497; doi:10.3390/ molecules26061497.

16. Bo Zeng, Chong Wang, Pansong Zhang, Zisheng Guo, Lin Chen, Kangmin Duan. Heat Shock Protein DnaJ in Pseudomonas aeruginosa Affects Biofilm Formation via Pyocyanin Production. Microorganisms. 2020 Mar 12;8(3). pii: E395. doi: 10.3390/ microorganisms8030395.

17. Zhao K, Kang W, Liu Q, Li Y, Liu Q, Jiang W, Zhuang Y, Guo Z, Yu Z, Li X, Wang C, Yao N, Sun Y. Genotypes and transmitted drug resistance among treatment-naive HIV-1-infected patients in a northwestern province, China: trends from 2003 to 2013. PLoS One, 2014 Oct 15;9(10):e109821. doi: 10.1371/journal.pone. 0109821. eCollection 2014.

科研项目：

1. 国家自然科学基金联合基金重点支持项目，U24A20601，子课题负责人；

2. 陕西省自然科学基础研究计划一般面上项目，2023-JC-YB-214，负责人；

3. 陕西省自然科学基础研究计划青年人才项目，2016JQ3034，负责人；

4. 陕西省教育厅专项科研计划项目，14JK1739，负责人；

5. 陕西基础科学（化学、生物学）研究院科学研究计划青年项目，22JHQ059，负责人；

6. 陕西省重点实验室开放课题基金，21LELE01，负责人；

7. 四川省重点实验室开放课题基金，ARRLKF24-06，负责人；

8. 西安市引进海外高层次人才智力项目，2022JH-GCRC-0139，负责人；

9. 国家重点研发计划，2021YFC1808902，子课题参与人；

10. 国家自然科学基金面上项目（31570131、22077099、22171223、22276148及42372023），参与人；

11. 陕西省重点研发项目，2025NC-YBXM-104，第一参与人；

教育教学

1. 参与或负责授课：《微生物学》、《Geobiology》（地质学系联合授课；国家级一流本科课程）、《普通病毒学》、《微生物学实验》以及《分子免疫学》等；

2. 西北大学第十一届青年教师讲课比赛，一等奖（理工组）；

3. 西北大学教学年度优秀教师；

4. 西北大学本科教学评估优秀；

5. 陕西省省级一流本科课程（虚拟仿真实验教学），第1参与人；

学生指导

1. 陕西省2022年优秀科普创作作品科普文章类，一等奖；共同指导教师；

2. 国家级大学生创新创业训练计划项目，202110697044，指导教师；

3. 国家级大学生创新创业训练计划项目，201710697043，指导教师；

4. 全国大学生生命科学竞赛（科学探究类），2022-61790，指导教师；

5. 西北大学暑期社会实践项目；2017；指导教师；

校企合作

1. 2023年陕西省科技工作者创新创业大赛，企业/西北大学，一等奖，负责人；

2. 校企合作横向项目，7项，负责人。