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崔亚丽
发布时间:2020-05-21      作者:    点击:[]    分享到:

崔亚丽,西北大学生命科学与医学部博士生导师,二级教授,国家微检测系统工程技术研究中心副主任,陕西省纳米生物医学检测工程研究中心主任,陕西省“四主体一联合”体外诊断创新校企联合研究中心主任,“陕西省纳米生物医学检测重点创新团队”带头人,西北大学智慧医疗与生命愿景研究院首席科学家。崔亚丽于2000年毕业于西安交通大学,获生物医学专业博士学位。目前是第11届、第12届陕西省政协委员,民盟陕西省委常委,民盟中央科技委员会委员,民盟西北大学主委。担任中国医疗器械行业协会现场快速检测分会副主委,中国药理学会药物基因组学分会常委,中国生物医学工程学会纳米医学与工程分会委员,全国卫生产业企业管理协会医学检验专家委员会副秘书长,陕西省生物化学与分子生物学学会常务理事,陕西省药学会常务理事等社会职务;曾获“陕西省有突出贡献专家”、“陕西省三八红旗手”、“三秦巾帼十杰”、“全国三八红旗手”、“全国妇女创先争优先进个人”、“苏州高新区科技创新创业领军人才”、“苏州姑苏创新创业领军人才”等荣誉称号。

崔亚丽教授在纳米生物技术和纳米医学领域从事工作近二十年,发明了具有我国自主知识产权的金磁微粒(GoldMag Particles),领导团队围绕磁性微粒开展重大疾病诊疗的研究和技术转化。主持完成国家“863”计划、国家自然科学基金、国家重大科技成果转化项目、“十二.”国家重大新药创制专项、国家重大传染病防治专项、国家自然科学基金等10余项国家级课题研究。发表论文70余篇,申报专利60余项。GoldMagÒ金磁微粒”获第十九届全国发明展览会金奖、发明家协会国际联合会颁发“最佳创新奖”。获陕西省科学技术奖一等奖1项,二等奖2项。获授权发明专利45项,(其中美国发明专利2项)。团队发明的“金磁微粒免疫层析法”和“PCR-金磁微粒层析法”得到了国家药监总局的认可,13个诊断试剂盒产品获得了欧盟CE认证,30个诊断试剂盒/仪器产品获得了国家食药监总局的医疗器械注册证书,其中,MTHFR C677T基因检测试剂盒(PCR-金磁微粒法)被国家食药监总局认定为国家“创新医疗器械”,被科技部社发司纳入《创新医疗器械产品目录》。产品在400余家医疗机构得到应用。

联系方式:

电话:0086-29-88302383 13572288901手机E-mailyalicui@nwu.edu.cn

通讯地址:陕西省西安市西北大学386信箱  邮政编码:710069


一、个人情况

基本信息:

民族:汉             籍贯:山东胶南

学位:博士       专业:生物医学工程

任职情况:

西北大学教授(二级岗位),博士生导师

国家微检测系统工程技术研究中心副主任

陕西省纳米生物医学检测工程研究中心主任

陕西省“四主体一联合”体外诊断创新校企联合研究中心主任

“陕西省纳米生物医学检测重点创新团队”带头人

西北大学智慧医疗与生命愿景研究院首席科学家

西北大学学位委员会委员

社会兼职:

陕西省政协委员(2013年)

陕西省生物化学与分子生物学学会常务理事(2006年)

中国医学装备协会POCT分委会常务委员(2016年)

中国药理学会药物基因组学分会常委(2015年)

中国生物医学与工程学会纳米医学与工程分会委员(2015年)

荣誉称号:

陕西省有突出贡献专家(2005年)

陕西省教育系统“五一”巾帼标兵(2007年)

陕西省三八红旗手(2011年)

陕西省“三秦巾帼十杰”(2011年)

全国三八红旗手(2012年)

全国创先争优先进个人(2012年)


二、教育经历

1983.9~1987.6 陕西师范大学化学教育专业,理学学士学位

1987.9~1990.6 西北大学无机化学专业,理学硕士学位

1997.2~2000.6 西安交通大学生物医学工程专业,获工学博士学位


三、工作经历:

1990.07~1992.11 陕西师范大学化学系,助教

1992.12~2000.11 陕西师范大学化学系,讲师

2000.12~2002.03 陕西师范大学化学与材料科学学院,副教授

2002.04~2004.11 西北大学生命科学院/国家微检测系统工程技术研究中心,副教授

2004.12~至今 西北大学生命科学院/国家微检测系统工程技术研究中心,教授

期间:20089~12月在德国明斯特大学做访问教授


四、学科建设与教学工作

学科建设:

主持/完成项目:

1. 生物化学与分子生物学国家重点培育学科,陕西省普通高校重点学科建设专项,2008~2013,经费:440万元

2. 《生物化学与分子生物学进展》,西北大学研究生重点课程建设项目,2010~2013

3. 《生物化学》,西北大学精品课程建设项目,2003~2005

课程教学:

1. 《生物化学与分子生物学进展》研究生学位课

2. 《生物化学》本科生基础课

3. 《纳米生物技术》博士生专业选修课

4. 《生物化学与分子生物学技术》研究生选修课


五、主持国家级科研项目

课题名称:核酸适配体-纳米金磁微粒复合探针对ARMS-PCR产物捕获及MTHFR C677T 基因分型层析检测新方法研究

项目来源:国家自然科学基金面上项目

任务来源:国家自然科学基金委

项目编号:81772289

起止年限:201801202112

   费:56万元


课题名称:个体化用药相关重要生物标志物及其新型检测试剂盒研发关键技术

项目来源:国家“重大新药创制”科技重大专项

任务来源:国家科技部、国家卫生部

项目编号:2012ZX09506001

起止年限:201201月至201512

   费:4135.85万元

(课题首席科学家,子课题单位包括中山大学、东南大学、上海交通大学、清华大学深圳研究院、中国科学院大连化物所、广州益善、杭州中肽、北京爱普易等)


课题名称:基于金磁颗粒免疫层析及比浊免疫技术的系列快速检测试剂的研制

项目来源:国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项

“传染病现场快速诊断试剂的研制”课题之子课题8

任务来源:国家科技部、国家卫生部

项目编号:2013ZX10004804008

起止年限:201301月至201512

   费:234.25万元


课题名称:药物代谢酶基因SNP检测生物芯片

项目来源:国家高技术研究发展计划(863)生物芯片重点项目

任务来源:国家科技部

项目编号:2006AA020705

起止年限:2006.12~2010.12

   费:999万元


课题名称:血液代用品中病源体的检测和净化技术的开发研究

项目来源:国家高技术研究发展计划(863)项目

任务来源:国家科技部

项目编号:2005AA205220

起止年月:2005.1 ~2005.12

   费:200万元


课题名称:食品中b-兴奋剂检测技术的开发及应用

项目来源:国家高技术研究发展计划(863)项目

任务来源:国家科技部

项目编号:2003AA2Z2080              

起止年月:2003.8~2005.12

   费:150万元


课题名称:SNP检测技术的开发研究

项目来源:国家高技术研究发展计划(863)项目

任务来源:国家科技部

项目编号:2001AA224032

 起止年月:2001.01~2003.12

   费:30万元


课题名称:GoldMag®-金磁微粒系列诊断试剂盒的产业化

项目来源:2010年国家重大科技成果转化项目

任务来源:国家工信部 、财政部

起止年月:2011.01~2012.12

   费:480万元


课题名称:以DNA介导的Fe3O4/Au复合微粒的组装研究

项目来源:国家自然科学基金项目

任务来源:国家自然科学基金委

项目编号:20273050

起止年月:2003.1~2005.12

   费:25万元

六、 代表性论文:

1.  Alphons J.M. Vermorken, Jingjing Zhu, Paul Holvoet, Yali Cui. The marker of cobalamin deficiency, plasma methylmalonic acid, may help identifying lysosomal iron trapping in patients. Its possible utility for heart failure. Redox Biology, 2021, 44, 102011.

2.  Jiaxing Zhang, Xiaonan Liu, Sinong Zhang, Yu Cai, Kang Ma, Kai Hua, Yali Cui. A site-specific DNA methylation biosensor for both visual and magnetic determination based on lateral flow assay. Analyst, 2021, 146(7) 2248-2254.

3.  Xiaonan Liu, Chao Zhang, Sinong Zhang, Yu Cai, Kai Hua, Yali Cui. One-step determination of deletion mutation based on loop-mediated isothermal amplification. Analytical Biochemistry, 2021, 616, 114087.

4.  Xiaonan Liu, Jiaxing Zhang, Yu Cai, Sinong Zhang, Kang Ma, Kai Hua, Yali Cui. A novel DNA methylation biosensor by combination of isothermal amplification and lateral flow device. Sensors and Actuators B: Chemical, 2021, 333, 129624.

5.  Xuemin Yang, Jiangping Liang, Xiaojuan Huang, Xiangrong Wang, Yang Sun, Chen Dong, Yali Cui, Wenli Hui. A Novel PCR Method for Detecting ACE Gene Insertion/Deletion Polymorphisms and its Clinical Application. Biological procedures online, 2021, 7, 23(1),2

6.  Lihua He, Kang Ma, Xiaonan Liu, Huixia Li, Lei Zhang, Miaomiao Tian, Zuhong Tian, Yujie Qiang, Yali Cui, Kai Hua. The role of morphology, shell composition and protein corona formation in Au/Fe3O4 composite nanoparticle mediated macrophage responses. Journal of Materials Chemistry B, 2021, 9, 6387-6395

7.  Yu Cai, Sinong Zhang, Chen Dong, Jiangcun Yang, Ting Ma, Hua Zhang, Yali Cui, Wenli Hui. Lateral flow immunoassay based on gold magnetic nanoparticles for the protein quantitative detection: Prostate-specific antigen. Analytical Biochemistry, 2021, 15, 627,114265.

8.  Houli li, Zhiyi Luo, Mingli Peng, Lili Guo, Fuqiang Li, Weiyi Feng, Yali Cui. Doxorubicin Loaded Dextran-coated Superparamagnetic Iron Oxide Nanoparticles with Sustained Release Property: Intracellular Uptake, Pharmacokinetics, and Biodistribution Study. Current Pharmaceutical Biotechnology, 2021.

9.  Sinong Zhang, Yu Cai, Jiaxing Zhang, Xiaonan Liu, Lihua He, Long Cheng, Kai Hua,Wenli Hui, Juanli Zhu, Yinsheng Wan, Yali Cui. Tetra-primers ARMS-PCR with GoldMag Lateral Flow Assay for Genotyping: A Simultaneous Visual Detection of Both Alleles. Nanoscale, 2020, 12, 10098.

10. Xing Yan, Ma FanFan, Peng MingLi, Ma XiangRong, Zhang Ya, Cui YaLi. Bifunctional sodium tartrate as stabilizer and reductant for the facile synthesis of Fe3O4/Ag nanocomposites with catalytic activity. Journal of Magnetism and Magnetic Materials, 2019, 471:133-141.

11. Yan Xuhong, Zhang Sinong, Liang Jianping, Cai Yu, Zhu Juanli, Zhang Chao, Li Desheng, Hua Kai, Cui Yali, Hui Wenli. A PCR-lateral flow assay system based on gold magnetic nanoparticles for CYP2C19 genotyping and its clinical applications. Artif Cells Nanomed Biotechnol, 2019, 47(1):636-643.

12. Xiaonan Liu, Chao Zhang, Kai Hua, Jianping Liang, Hang Li, Ting Ma, Juanli Zhu,Yali Cui. Direct genotyping from whole blood using alkaline polyethylene glycol. Analytical Biochemistry, 2019, 582:113351.

13. Xiaonan Liu, Chao Zhang, Mengye Zhao, Kewu Liu, Hang Li, Ningning Li, Linlin Gao, Xuemin Yang, Ting Ma, Juanli Zhu, Wenli Hui, Kai Hua, Yali Cui. A direct isothermal amplification system adapted for rapid SNP genotyping of multifarious sample types. Biosensors & bioelectronics, 2018, 115: 70–76.

14. Chao Zhang, Xiaonan Liu, Yao Yao, Kewu Liu, Wenli Hui, Juanli Zhu, Yaling Dou, Kai Hua, Mingli Peng, Zuankai Wang, Alphonsus J.M. Vermorken, Yali Cui. Genotyping of Multiple Clinical Samples with a Combined Direct PCR and Magnetic Lateral Flow Assay. iScience. 2018, 7: 170-179.

15. Xiaonan Liu, Chao Zhang, Kewu Liu, Han Wang, Chaoxia Lu, Hang Li, Kai Hua, Juanli Zhu, Wenli Hui, Yali Cui, Xue Zhang. Multiple SNPs Detection Based on Lateral Flow Assay for Phenylketonuria Diagnostic. Analytical Chemistry. 2018, 90(5): 3430-3436.

16. Lixia Zhang, Qinlu Zhang, Min Gao, Zhiyi Luo, Ying Zhang, Xiaoxia Li, Kai Hua, Chao Zhang, Wenting Lai, Yali Cui. Clinical experimental study of GoldMag (R) immunochromatography in high sensitive C reactive protein detection from whole blood and plasma. Journal of Magnetism and Magnetic Materials, 2019, 473: 68–73

17. Xibo Li, Ningning Li, Sidlauskas, Kastytis, Houli Li, Chao Zhang, Mingli Peng, Qinlu Zhang, Kai Hua, Lili Guo, Fuqiang Li, Ying Zhang, Mingwei Chen, Guanjun Zhang, Yihang Pan, Linlin Gao, Yali Cui. Doxorubicin-Loaded Dextran-Modified GoldMag Nanoparticles for Targeting Hepatocellular Carcinoma. Journal of Biomedical Nanotechnology, 2018, 14(6):1135-1146.

18. Yan Xing, Qin Gao, Yanmin Zhao, Le Ma, Kang Yong Loh, Mingli Peng, Chao Chen, Yali Cui. The improved sensitive detection of C-reactive protein based on the chemiluminescence immunoassay by employing monodispersed PAA-Au/Fe3O4 nanoparticles and zwitterionic glycerophosphoryl choline. Journal of Materials Chemistry B, 2017, 5, 3919.

19. Ting Ma, Mengdan Zhang, Yinsheng Wan, Yali Cui, Le Ma. Preparation of an Acridinium Ester-Labeled Antibody and Its Application in GoldMag Nanoparticle-Based, Ultrasensitive Chemiluminescence Immunoassay for the Detection of Human Epididymis Protein 4. Micromachines, 2017, 8, 149

20. Xiaomei Zhang, Qinlu Zhang, Ting Ma, Qian Liu, Songdi Wu, Kai Hua, Chao Zhang, Mingwei Chen, Yali Cui. Enhanced Stability of Gold Magnetic Nanoparticles with Poly(4-styrenesulfonic acid-co-maleic acid): Tailored Optical Properties for Protein Detection. Nanoscale Research Letters, 2017, 12(1):547.

21. Xianying Li, Chao Zhang, Qinlu Zhang, Juanli Zhu, Qian Liu, Mingwei Chen, Xuemin Yang, Wenli Hui, Yali Cui. Sensitive genotyping of mutations in the EGFR gene from NSCLC patients using PCR-GoldMag lateral flow device. Scientific Reports, 2017, 7(1):10.

22. Ting Lian, Wenli Hui, Xianying Li, Chao Zhang, Juanli Zhu, Rui Li, Yinsheng Wan, Yali Cui. Apolipoprotein E genotyping using PCR-GoldMag lateral flow assay and its clinical applications. Molecular Medicine Reports, 2016, 14(5):4153-4161.

23. Chao Zhang, Yao Yao, Juanli Zhu, Sinong Zhang, Shanshan Zhang, Hua Wei, Wenli Hui, Yali Cui. Establishment and application of a real-time loop-mediated isothermal amplification system for the detection of CYP2C19 polymorphisms. Scientific Reports, 2016, DOI: 10.1038/srep26533

24. Wenli Hui, Sinong Zhang, Chao Zhang, Yinsheng Wan, Juanli Zhu, Gang Zhao, Songdi Wu, Dujuan Xi, Qinlu Zhang, Ningning Li, Yali Cui. A Novel Lateral Flow Assay Based on GoldMag Nanoparticles and Its Clinical Applications for Genotyping of MTHFR C677T Polymorphisms. Nanoscale, 8:3579-3587, 2016.

25. Xingxing Li, Qinlu Zhang, Peng Hou, Mingwei Chen, Wenli Hui, Alphons Vermorken, Zhiyi Luo, Hong Li, Qin Li and Yali Cui. Gold magnetic nanoparticle conjugate-based lateral flow assay for the detection of IgM class antibodies related to TORCH infections, International Journal of Molecular Medcine, 36(5):1319-26, 2015.

26. Chao Zhang, Juanli Zhu, Jiangcun Yang, Yingsheng Wan, Ting Ma, Yali Cui. Determination of ABO blood group genotypes using the realtime loopmediated isothermal amplification method, Molecular Medicine Reports, 12: 5963-5966, 2015.

27. Mingli Peng , Houli Li, Zhiyi Luo, Jian Kong, Yinsheng Wan, Hongxin Niu, Fons Vermorken, Wim Van de Ven, Xikun Zhang, Fuqiang Li, Lili Guo, Lemin Zheng, Yali Cui. Dextran-coated superparamagnetic particle iron oxide as a potential drug carrier in vivo, Nanoscale, 7: 1155-1162, 2015.

28. Yan Xing, Yanyan Jin, Jianchao Si, Mingli Peng, Xiaofang Wang, Chao Chen, Yali Cui, Controllable synthesis and characterization of Fe3O4/Au composite nanoparticles. Journal of Magnetism and Magnetic Materials, 150156, 2015.

29. Xiaowen Huang, Wenli Hui, Chonglei Hao, Wanqing Yue, Mengsu Yang, Yali Cui, Zuankai Wang. On-site formation of emulsions by controlled air plugs. Small, 10 (4): 621, 2014.

30. Jian-Chao Si, Yan Xing, Ming-Li Peng, Chao Zhang,c Norbert Buske, Chao Chenbc and Ya-Li Cui. Solvothermal synthesis of tunable iron oxide nanorods and their transfer from organic phase to water phase. CrystEngComm, 16: 512-516, 2014.

31. Dong Yang, Jianzhong Ma, Qinlu Zhang, Ningning Li, Jiangcun Yang, Paul Ananda Raju, Mingli Peng, Yanling Luo, Wenli Hui, Chao Chen, Yali Cui. Polyelectrolyte Coated Gold Magnetic Nanoparticles for Immunoassay Development: Toward Point of Care Diagnostics for Syphilis Screening. Analytical Chemistry, 85 (14): 6688–6695, 2013.

32. Dong Yang, Jianzhong Ma, Min Gao, Mingli Peng, Yanling Luo, Wenli Hui, Chao Chen, Zuankai Wang, Yali Cui. Suppression of composite nanoparticle aggregation through steric stabilization and ligand exchange for colorimetric protein detection. RSC Advances, 3: 9681-9686, 2013.

33. Jingjing Zhu, W. J. Van de Ven, T Verbiest, G Koeckelberghs, Chao Chen, Yali Cui, A J Vermorken. Polyphenols can inhibit furin in vitro as a result of the reactivity of their auto-oxidation products to proteins. Current Medicinal Chemistry, 20(6): 840-50, 2013.

34. Xibo Li, Mingling Peng, Raju Ananda Paul, Qinlu Zhang, Yue Hu, Yanyan Jin, and Yali Cui. Dextran-Coated GoldMag Nanoparticles Enhance the Colloidal Stability and Controlled-Release of Doxorubicin. IEEE Transactions on Magnetics, 49(1):359 - 363, 2013.

35. Dong Yang, Jianzhong Ma, Mingli Peng, Qinlu Zhang, Yanling Luo, Wenli Hui, Tianbo Jin, Yali Cui. Building NanoSPR biosensor systems based on gold magnetic composite nanoparticles. Journal of Nanoscience and Nanotechnology, 13(8): 5485-5492, 2013 .

36. Xu Chao, Zhuoli Zhang, Lili Guo, Jingjing Zhu, Mingli Peng, Alphonsus J. M. Vermorken,Wim J. M. Van de Ven, Chao Chen, Yali Cui. A Novel Magnetic Nanoparticle Drug Carrier for Enhanced Cancer Chemotherapy. PLOS One, 7 (10): e40388, 2012.

37. Jing Ren, Zhuoli Zhang, Fang Wang, Yong Yang, Ying Liu, Guangquan Wei, Angang Yang, Rui Zhang, Yi Huan, Yali Cui, Andrew C Larson. MRI of prostate stem cell antigen expression in prostate tumor. Nanomedicine, 7(5): 691–703, 2012.

38. Jingjing Zhu, J. Declercq, J. W.M. Creemers, Chao Chen, Yali Cui, W. J.M. Van de Ven , A. J.M. Vermorken. Limitations of Inhibitory Activities of Polyphenols on Furin-Mediated Substrate Processing. Current Medicinal Chemistry, 19(21): 3641-3450, 2012.

39. Wenli Hui, Feng Shi, Kunping Yan, Mingli Peng, Xiao Cheng, Yanling Luo, Xuemei Chen, V. A. L. Roy, Yali Cui, Zuankai Wang. Fe3O4/Au/Fe3O4 nanoflowers exhibiting tunable saturation magnetization and enhanced bioconjugation. Nanoscale, 4:747-751, 2012.

40. Miao Wang, Ming-Li Peng, Wu Cheng, Ya-Li Cui, and Chao Chen. A Novel Approach for Transferring Oleic Acid Capped Iron Oxide Nanoparticles to Water Phase. Journal of Nanoscience and Nanotechnology, 11: 36883691, 2011.

41. Guodong Feng, Luan Jiang, Puhong Wen, Yali Cui, Hong Li, Daodao Hu. A new ion-exchange adsorbent with paramagnetic properties for the separation of genomic DNA. Analyst, 22(136): 4822-4829, 2011.

42. Zhixia Li, Mingli Peng, Yanyan Jin, Xiaofang Wang, Yali Cui, Chao Chen. Synthesis of gamma-Fe2O3/SiO2/Au magnetic composites for immobilization of bovine serum albumin. Chinese Science Bulletin, 27(56): 2911-2915, 2011.

43. Feng Shi, Wenli Hui, Yali Cui and Chao Chen. Surface modification and characterization of Fe3O4/Au composite nanoparticles. Nano, 6(2): 145-151, 2011.

44. Xu Chao, Lili Guo, Yingyong Zhao, Kai Hua, Mingli Peng, Chao Chen, and Yali Cui. PEG-modified GoldMag nanoparticles (PGMNs) combined with the magnetic field for local drug delivery. Journal of Drug Targeting, 19(3): 161–170, 2011.

45. Xu Chao, Feng Shi, Yingyong Zhao, Ke Li, Mingli Peng, Chao Chen, Yali Cui. Cytotoxicity of Fe3O4/Au composite nanoparticles loaded with doxorubicin combined with magnetic field. Pharmazie65: 500-504, 2010.

46. Hongli Zhu, Penggao Dai, Wei Zhang, Erfang Chen, Wenxian Han, Chao Chen, Yali Cui. Enzymic Synthesis of Gastrodin through Microbial Transformation and Purification of Gastrodin Biosynthesis Enzyme. Biological & Pharmaceutical Bulletin, 10(33): 1680-1684, 2010.

47. Guodong Feng, Daodao Hu, Lei Yang, Yali Cui, Xinai Cui, Hong Li. Immobilized-metal affinity chromatography adsorbent with paramagnetism and its application in purification of histidine-tagged proteins. Separation and Purification Technology, 74(2): 253-260, 2010.

48. Yitong Tang, Tingting Geng, Xiaofang Xin, Chao Chen, Yali Cui. Coupling proteins to amine-terminated magnetic particles activated with 1,4-phenylene diisothiocyanate. Chin. J. Chem. 28: 627~632, 2010.

49. Caiquan Zhang, Yali Cui, Di Di, Kunping Yan, Chen Chao, Mingli Peng. Solvothermal synthesis of uniform magnetite microspheres. Functional Materials Letters. 3(2): 125-129, 2010.

50. A.J.M Vermorken, J Zhu, W.J.M. VAN DE VEN, Y. CUI and J.P. FRYNS. Curcumin for the prevention of progression in monoclonal gammopathy of undetermined significance: A word of caution (Review). Experimental & Therapeutic Medicine, 1:265-269, 2010.

51. Mingli Peng, Yanhong Liu, Hua Zhang, Yali Cui, Gaohong Zhai, Chao Chen. Photostability study of doxorubicin aqueous solutionenhanced by inclusion interaction between doxorubicin and hydroxypropyl-β-cyclodextrin. Chinese Journal of Chemistry, 28(7): 1291-1295, 2010.

52. Ming Zhao, Xianqing Zhang, Sen Wang, Chao Chen, Yali Cui. A simple method for purification of genomic DNA from whole blood using Fe3O4/Au composite particles as a carrier. Journal of Medical Colleges of PLA, 24: 239–243, 2009.

53. Hua Zhang, Mingli Peng, Yali Cui, Chao Chen. Magnetic HP-b-CD composite nanoparticle: synthesis, characterization and application as a carrier of doxorubicin in vitro. Chinese Journal of Chemistry, 26: 1737-1740, 2008.

54. Zhefei Li, L Jian, Huirong Wang, Yali Cui. Flow injection chemiluminescent determination of clenbuterol using GoldMag particles as carrier. Food Additives and Contaminants, 24 (1): 21-25, 2007.

55. An Yu, Tingting Geng, Qiang Fu, Chao Chen and Yali Cui. Biotin-avidin amplified magnetic immunoassay for hepatitis B surface antigen detection using GoldMag nanoparticles. Journal of Magnetism and Magnetic Materials, 311: 401~404, 2007.

56. Zhifeng Zhang, Hongli Zhu, Yitong Tang, Ting Cui, Tingting Geng, Chao Chen, Yali Cui. Preparation and application of streptavidin magnetic particles. Science in China Series B: Chemistry. 50(1): 127-134, 2007.

57. Shujuan Li, Yongliang Sun, Daodao Hu, Chao Chen, Yali Cui. Preparation of Metal Chelate Affinity Chromatographic Medium and Its Application in the Purification of 6×Histidine-tagged Protein. Chinese Journal of Biotechnology. 23(5), 941−946, 2007.

58. Yali Cui Lianying ZhangJing SuCaifeng ZhangQi LiTing CuiBoquan JinChao Chen. Synthesis of GoldMag particles with assembled structure and their applications in immunoassay. Science in China (Series B), 49(6): 534~540, 2006.

59. Yali Cui, Yani Wang, Wenli Hui, Zhifeng Zhang, Xiaofang Xin, Chao Chen. The Synthesis of GoldMag Nano-particles and its Application for Antibody Immobilization. Biomedical Microdevices, 7(2): 153~156, 2005.

60. Yali Cui Wenli HuiJing SuYani WangChao Chen. Fe3O4/Au composite nanoparticles and their optical properties. Science in China (Series B), 48(1): 273~278, 2005.

61. Yali Cui, Wenli Hui, Huirong Wang, Lijun Wang. Preparation and characterization of Fe3O4/Au composite particles. Science in China (Series B), 47(2): 152~158, 2004.

62. Daodao Hu, Yali Cui, Yu Fang. A Simple apparatus for gravitational sedimentation. J. Chem. Educ., 79(5): 623, 2002.

63. Yali Cui, daodao Hu, Yu Fang, Jianbiao Ma. Preparation and mechanism of Fe3O4/Au core/shell super-paramagnetic microspheres. Science in China (series B) 44(4): 404~410, 2001.

64. Daodao Hu, Yali Cui, Xiaoli Dong, Yu Fang. Studies on CoSalen immobilized onto N-(4-pyridylmethylidene)-chitosan. Reactive & Functional Polymers, 48: 201~207, 2001.

65. Mingzhen Wang; Junchao Qiang; Yu Fang; Daodao Hu; Yali Cui. Preparation and properties of chitosan-poly(N-isopropylacrylamide) semi-IPN hydrogelsJ Polym Sci, Part A: Polym Chem. 38(3): 474~481, 2000.

66. Yu Fang; Shouxin Liu; Daodao Hu; Yali Cui. Complexes of chitosan and poly(methacrylic acid) studied by fluorescence techniques, Polymer Bulletin, 43(4): 1230~1237, 1999.


七、获授权代表性发明专利(第1发明人)

1. 磁性荧光微球及其制备方法和采用该磁性荧光微球进行生物分子检测的方法,ZL 02139365.6

2. 一种核/壳型超顺磁性复合微粒及其制备方法与应用,ZL 03124061.5

3. 以磁性微球介导的微留体分析系统及其检测方法,ZL 03134319.8

4. 一种组装型磁性复合微粒及其制备方法与应用,ZL 03153486.4

5. 一种亲和素/链亲和素磁性复合微粒及其制备方法与用途,ZL 200510096212.5

6. 利用金磁微粒进行细胞分选的方法,ZL 200610104760.2

7. 利用纳米金磁微粒进行生物分子检测的方法,ZL 200610104759.X

8. 利用金磁微粒分离mRNA的方法,ZL 200610104756.6

9. 以金磁微粒为载体检测抗双链DNA抗体的方法,ZL 200610104758.5

10. 利用金磁微粒纯化DNA的方法,ZL 200610104755.1

11. 多糖金磁复合微粒载药体及其制备方法,ZL 200810236540.4

12. 一种基于卵黄抗体的免疫磁性微粒的制备方法,ZL 200910219283.8

13. 一种基于金磁微粒进行免疫沉淀反应的方法,ZL 200910254442.8

14. 聚甲基丙烯酸磁性复合微球及其制备方法,ZL 200910218934.1

15. 表面修饰阳离子的磁性二氧化硅微球的制备方法,ZL200910219011.8

16. 一种纳米磁性氧化铁粒子组装在金颗粒表面的复合微粒及制备方法,ZL 200910254443.2

17. 一种用金磁微粒纯化总核酸的方法,ZL 200910219125.2

18. 一种抗人血清/浆中高丰度蛋白卵黄抗体IgY的制备方法及其应用,ZL200910254437.7

19. 一种用于细胞转染的PEI修饰的金磁微粒的制备方法,ZL 200910254439.6

20. 一种亲和素/链亲和素磁性复合微粒用于细胞分选的方法,ZL 200910254488.X

21. 表面修饰有异硫氰酸根活性基团的磁性微粒的制备方法,ZL 200910254487.5

22. 一种用亲和素/链亲和素磁性复合微粒对生物分子进行免疫学检测的方法,ZL 200910254438.1

23. 金磁微粒标记免疫层析快速检测方法,ZL 201010222447.5

24. Super-paramagnetic composite particle with core/shell structurepreparation method and use thereof,美国发明专利US7,175,912


八、获奖情况:

1. 基于GoldMag金磁微粒的适宜检测技术的创建及临床应用,中国发明协会创新奖二等奖,2020年,第1完成人。

2. PCR-金磁微粒层析法”基因检测技术的开发及应用,陕西省教育厅科学技术二等, 2017, 2完成人

3. Fe3O4/Au磁性复合微粒在生物医学领域中的应用与开发陕西省教育厅科学技术一等

, 2004, 1完成人

4. 磁性复合微粒的合成及其应用研究,陕西省教育厅科学技术20051完成人

5. 人乳头瘤病毒基因分型液态芯片的构建与临床应用研究陕西省科学技术二等奖2010年,5完成人

6. 静态荧光技术在高分子胶体与界面科学中的应用研究陕西省科学技术二等奖, 20045完成人

7. 一种核/壳型超顺磁性复合微粒的结构及制备方法与应用,第十九届全国发明展览会金奖,20101完成人

8. 一种核/壳型超顺磁性复合微粒的结构及制备方法与应用,发明家协会国际联合会颁发的最佳发明创新奖,20101完成人

9. 一种核/壳型超顺磁性复合微粒的结构及制备方法与应用,陕西省首届发明创业奖20101完成人

10. 磁性纳米载药粒子在肝癌靶向治疗研究中的应用,陕西高等学校科学技术一等奖,2012年,2完成人


九、成果转化情况

序号

产品名称

注册(备案)号

1

MTHFR C677T基因检测试剂盒(PCR-金磁微粒层析法)

国械注准20153401148

2

梅毒螺旋体抗体检测试剂盒(金磁微粒免疫层析法)

国食药监械(准)字20143401114

3

高敏C反应蛋白检测试剂盒(磁酶免化学发光法)

陕械注准20142400021

4

氨基末端脑钠肽前体检测试剂盒(金磁微粒免疫层析法)

陕械注准20142400034

5

高敏C反应蛋白检测试剂盒(金磁微粒免疫层析法)

陕械注准20142400022

6

肌红蛋白检测试剂盒(金磁微粒免疫层析法)

陕械注准20152400091

7

D-二聚体检测试剂盒(金磁微粒免疫层析法)

陕械注准20152400092

8

心脏型脂肪酸结合蛋白检测试剂盒(金磁微粒免疫层析法)

陕械注准20162400023

9

降钙素原检测试剂盒(金磁微粒免疫层析法)

陕械注准20162400024

10

肌酸激酶同工酶检测试剂盒(金磁微粒免疫层析法)

陕械注准20162400043

11

心肌肌钙蛋白I检测试剂盒(金磁微粒免疫层析法)

陕械注准20162400042

12

S100蛋白检测试剂盒(金磁微粒免疫层析法)

陕械注准20162400041

13

磁定量免疫分析仪(GM-MICTv2

陕械注准20162400044

14

全血基因组DNA分离试剂盒(磁性微粒法)

陕西械备20140001