个人简介

梁海华，博士、西北大学生命科学学院、教授，博士生导师。2009年博士毕业于西北大学微生物学专业，同年留校工作。其中2011年3月－2014年3月在芝加哥大学从事博士后研究。
通信地址：西北大学生命科学学院，西安市太白北路229号，邮编：710069
E-mail: lianghh@nwu.edu.cn
电话: 029-88303662
 
主要研究方向：病原微生物功能基因组学；细胞间信号传递途径； 细菌与宿主的相互作用；
 
抗生素的大量使用和滥用导致各种耐药病原菌的出现，为了阐述“耐药”机制，寻找抗细菌感染的新靶标，我们必须深入的了解病原菌的生理特征、致病机理、抗生素抗性以及与宿主免疫系统相互作用的分子机制。为此，我们将利用多种生物组学技术（如：转录组学，蛋白组学，代谢组学）寻找与其相关的蛋白，然后运用分子生物学、结构生物学、分子遗传学等手段来研究这些蛋白的功能，结构及其调节途径。我们的最终目标是以这些蛋白为新的靶标来开发新型抗菌药物，为控制病原菌的感染提供一个可靠的手段。

承担的科研项目

在研项目：
（1）国家自然科学基金委优秀青年项目：病原菌的致病和耐药机制，150万元，项目主持人。
（2）国家自然科学基金面上项目：铜绿假单胞菌藻酸盐（Alginate）合成相关蛋白的调控机制及功能研究，62万元，项目主持人。
（3）陕西省自然科学基金重点项目：铜绿假单胞菌中群体感应系统调节子Vfr调控途径的研究，项目主持人。

主要研究成果

代表性论文：(*通讯作者)，(1共同第一作者)
 
1. Qinqin Pu, Changpei Gan, Rongpeng Li, Yi Li, Shirui Tan, Xuefeng Li, Yuquan Wei, Lefu Lan, Xin Deng, Haihua Liang*, Feng Ma*, and Min Wu* (2017). Atg7 deficiency intensifies inflammasome activation and pyroptosis in Pseudomonas Sepsis. J Immunol. Online. doi: 10.4049/jimmunol.1601196
2. Huaping Kang1, Jianhua Gan1, Jingru Zhao1, Weina Kong, Jing Zhang, Miao Zhu, Fan Li, Yaqin Song, Jin Qin and Haihua Liang* (2017). Crystal structure of Pseudomonas aeruginosa RsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing. Nucleic Acids Res. 45 (2): 699-710.
3. Jingru Zhao, Xiang Yu, Miao Zhu, Huaping Kang, Jinbiao Ma, Jianhua Gan*, Xin Deng* and Haihua Liang* (2016). Structural and molecular mechanism of CdpR involved in quorum-sensing and bacterial virulence in Pseudomonas aeruginosa. PLoS Biol. 14 (4):e1002449. 
4. Weina Kong, Jingru Zhao, Huaping Kang, Miao Zhu, Xin Deng* and Haihua Liang* (2015). ChIP-seq reveals the global regulator AlgR mediating cyclic di-GMP synthesis in Pseudomonas aeruginosa. Nucleic Acids Res. 43 (17): 8268-8282.
5. Miao Zhu, Jingru Zhao, Huaping Kang, Weina Kong and Haihua Liang* (2016). Modulation of type III secretion system in Pseudomonas aeruginosa: Involvement of the PA4857 gene product. Front Microbiol. 28 (7): 1-7. 
6. Haihua Liang*, Xin Deng, Yan Ye and Min Wu* (2014). Molecular mechanism of master regulator VqsM mediating quorum-sensing and antibiotic resistance in Pseudomonas aeruginosa. Nucleic Acids Res. 42 (16): 10307-10320. 
7. Xin Deng1, Haihua Liang1, Chuan He, Lefu Lan* and Xiaoyan Tang* (2014). Molecular mechanisms of two-component system RhpRS regulating type III secretion system in Pseudomonas syringae. Nucleic Acids Res. 42 (18): 11472-11486. 
8. Haihua Liang, Xin Deng, Mike Bosscher, Quanjiang Ji, Mark P. Jensen and Chuan He* (2013). Engineering Bacterial two-component system PmrA/PmrB sense lanthanide ions. J Am Chem Soc. 135(6): 2037-2039. 
9. Fei Sun1, Haihua Liang1, Xiangqian kong, Sherrie Xie, Hoonsik Cho, Xin Deng, Quanjiang Ji, Haiyan Zhang, Sophie Alvarez, Leslie M. Hicks, Taeok Bae, Cheng Luo, Hualiang Jiang and Chuan He* (2012). Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA. Proc Natl Acad Sci USA. 109 (23): 9095-9100. 
10. Haihua Liang*, Xin Deng, Quanjiangji, Tuo Shen and Chuan He (2012). The Pseudomonas aeruginosa global regulator VqsR directly inhibits QscR to control quorum-sensing and virulence gene expression. J Bacteriol. 194 (12): 3098-3108.
11. Lixin Shen, Yanling Ma and Haihua Liang* (2012). Characterization of a novel gene related to antibiotic susceptibility in Pseudomonas aeruginosa. J Antibiot. 65 (2): 59-65.
12. Haihua Liang, Jiali Duan, Michael G Surette and Kangmin Duan* (2011). Identification of mutants with altered phenazine production in pseudomonas aeruginosa. J Med Microbiol. 60 (Pt1): 22-34.
13. Haihua Liang, Lingling Li and Kangmin Duan* (2009). Identification of a novel regulator of quorum sensing in Pseudomonas aeruginosa. FEMS Microbiol Lett. 293: 197-204.
14. Haihua Liang, Lingling LI, Zhaolin Dong, Michael G. Surette and Kangmin Duan* (2008). The YebC family protein PA0964 negatively regulates the Pseudomonas aeruginosa quinolone signal system and pyocyanin production. J Bacteriol. 190 (18): 6217-6227.
15. Xin Deng, Eranthie Weerapana, Olesya Ulanovskaya, Fei Sun, Haihua Liang, Quanjiang ji, Yan Ye, Ye Fu, Lu Zhou, Jiaxin Li, Haiyan Zhang, Chu Wang, Sophie AlvareZ, Leslie M. Hicks, Lefu Lan, Min Wu, Benjamin F. Cravatt* and Chuan He* (2013). Proteome-wide quantification and characterization of oxidation-sensitive cysteines in pathogenic bacteria. Cell Host & Microbe. 13: 358-370. 
16. Quanjiang Ji, Liang Zhang, Marcus B. Jones, Fei Sun, Xin Deng, Haihua Liang, Hoonsik Cho, Pedro Brugarolas, Yihe N. Gao, Scott N. Peterson, Lefu Lan, Taeok Bae and Chuan He* (2013). Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR. Proc Natl Acad Sci USA. 110 (13): 5010-5015. 

17. Liang Zhang, Xingyu Lu, Junyan Lu, Haihua Liang, Hualiang Jiang and Chuan He* (2012). Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA. Nat Chem Biol. 8 (4): 328-330.